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Article
Group penalized logistic regression differentiates between benign and malignant ovarian tumors
Ovarian cancer is one of the most common types of cancer in women. Correct differentiation between benign and malignant ovarian tumors is of immense importance in medical fields. In this paper, we introduce gr...
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Article
Penalized logistic regressions with technical indicators predict up and down trends
Correctly predicting up and down trends for stock prices is of immense important in the financial market. To further improve the prediction performance, in this paper we introduce five penalties: ridge, least ...
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Article
Open AccessMultilayered regulation of secondary metabolism in medicinal plants
Medicinal plants represent a huge reservoir of secondary metabolites (SMs), substances with significant pharmaceutical and industrial potential. However, obtaining secondary metabolites remains a challenge due...
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Article
Nucleotide Recognition by a Guanidinocalixarene Receptor in Aqueous Solution
Nucleotides participate in various physiological processes through their supramolecular interactions with biomolecules. Therefore, the molecular recognition of nucleotides became an important topic in supramole.....
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Article
Human epididymis protein 4 (HE4) is a novel immunohistochemical marker of neuroendocrine differentiation
Human epididymis protein 4 (HE4) is originally described as an epididymis specific protein and now clinically used as a serum marker for ovarian carcinoma. However, the expression of HE4 in neuroendocrine neop...
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Article
Raising the production of phloretin by alleviation of by-product of chalcone synthase in the engineered yeast
Phloretin is an important skin-lightening and depigmenting agent from the peel of apples. Although de novo production of phloretin has been realized in microbes using the natural pathway from plants, the efficien...
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Article
Open AccessConstructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design
Acetyl-CoA is a fundamental metabolite for all life on Earth, and is also a key starting point for the biosynthesis of a variety of industrial chemicals and natural products. Here we design and construct a Syn...
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Article
Open AccessEngineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches
The flavonoid extract from Erigeron breviscapus, breviscapine, has increasingly been used to treat cardio- and cerebrovascular diseases in China for more than 30 years, and plant supply of E. breviscapus is becom...
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Article
Open AccessBiosynthesis and engineering of kaempferol in Saccharomyces cerevisiae
Kaempferol is a flavonol with broad bioactivity of anti-oxidant, anti-cancer, anti-diabetic, anti-microbial, cardio-protective and anti-asthma. Microbial synthesis of kaempferol is a promising strategy because...
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Article
Open AccessEngineering microbial cell factories for the production of plant natural products: from design principles to industrial-scale production
Plant natural products (PNPs) are widely used as pharmaceuticals, nutraceuticals, seasonings, pigments, etc., with a huge commercial value on the global market. However, most of these PNPs are still being extr...
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Diaphragmatic Eventration in Sisters with Asparagine Synthetase Deficiency: A Novel Homozygous ASNS Mutation and Expanded Phenotype
Background: Asparagine Synthetase Deficiency (ASNSD; OMIM #615574) is a newly described rare autosomal recessive neurometabolic disorder, characterised by congenital microcephaly, severe psychomotor dela...
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Article
Open AccessDevelopment of a modularized two-step (M2S) chromosome integration technique for integration of multiple transcription units in Saccharomyces cerevisiae
Saccharomyces cerevisiae has already been used for heterologous production of fuel chemicals and valuable natural products. The establishment of complicated heterologous biosynthetic p...
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Article
Open AccessImproving the catalytic activity of isopentenyl phosphate kinase through protein coevolution analysis
Protein rational design has become more and more popular for protein engineering with the advantage of biological big-data. In this study, we described a method of rational design that is able to identify desi...
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Open AccessErratum: Auxenochlorella protothecoides and Prototheca wickerhamii plastid genome sequences give insight into the origins of non-photosynthetic algae
The forfeiting of photosynthetic capabilities has occurred independently many times throughout eukaryotic evolution. But almost all non-photosynthetic plants and algae still retain a colorless plastid and an a...
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Article
Open AccessAuxenochlorella protothecoides and Prototheca wickerhamii plastid genome sequences give insight into the origins of non-photosynthetic algae
The forfeiting of photosynthetic capabilities has occurred independently many times throughout eukaryotic evolution. But almost all non-photosynthetic plants and algae still retain a colorless plastid and an a...
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Article
Open AccessPleiotropy of the de novo-originated gene MDF1
MDF1 is a young de novo-originated gene from a non-coding sequence in baker's yeast, S. cerevisiae, which can suppress mating and promote vegetative growth. Our previous experiments successfully demonstrated how ...
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Article
Open AccessCoordinating Expression of RNA Binding Proteins with Their mRNA Targets
Post-transcriptional regulation by RNA binding proteins (RBPs) plays prominent roles in a variety of biological processes. In this study, by analyzing the global regulatory relationship between RBPs and their ...
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Article
Open AccessThe transcriptome landscape of Prochlorococcus MED4 and the factors for stabilizing the core genome
Gene gain and loss frequently occurs in the cyanobacterium Prochlorococcus, a phototroph that numerically dominates tropical and subtropical open oceans. However, little is known about the stabilization of its co...
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Article
A de novo originated gene depresses budding yeast mating pathway and is repressed by the protein encoded by its antisense strand
Recent transcription profiling studies have revealed an unexpectedly large proportion of antisense transcripts in eukaryotic genomes. These antisense genes seem to regulate gene expression by interacting with ...
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Article
Open AccessGene duplication in the genome of parasitic Giardia lamblia
Giardia are a group of widespread intestinal protozoan parasites in a number of vertebrates. Much evidence from G. lamblia indicated they might be the most primitive extant eukaryotes. When and how such a group o...
