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Article
Open AccessDecreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging
With advanced maternal age, abnormalities during oocyte meiosis increase significantly. Aneuploidy is an important reason for the reduction in the quality of aged oocytes. However, the molecular mechanism of a...
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Article
Open AccessA phospholipid:diacylglycerol acyltransferase is involved in the regulation of phospholipids homeostasis in oleaginous Aurantiochytrium sp.
Thraustochytrids have gained attention as a potential source for the production of docosahexaenoic acid (DHA), where DHA is predominantly stored in the form of triacylglycerol (TAG). The TAG biosynthesis pathw...
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Article
Open AccessThe incidence, risk factors and outcomes of acute kidney injury in critically ill patients undergoing emergency surgery: a prospective observational study
Without sufficient evidence in postoperative acute kidney injury (AKI) in critically ill patients undergoing emergency surgery, it is meaningful to explore the incidence, risk factors, and prognosis of postope...
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Article
Open AccessCathelicidin hCAP18/LL-37 promotes cell proliferation and suppresses antitumor activity of 1,25(OH)2D3 in hepatocellular carcinoma
Cathelicidin hCAP18/LL-37 can resist infection from various pathogens and is an essential component of the human immune system. Accumulating evidence has indicated that hCAP18/LL-37 plays a tissue-specific rol...
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Article
Open AccessCocktail biosynthesis of triacylglycerol by rational modulation of diacylglycerol acyltransferases in industrial oleaginous Aurantiochytrium
Triacylglycerol (TAG) is an important storage lipid in organisms, depending on the degree of unsaturation of fatty acid molecules attached to glycerol; it is usually used as the feedstock for nutrition or biod...
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Article
Research advances on arachidonic acid production by fermentation and genetic modification of Mortierella alpina
Arachidonic acid (ARA, 5, 8, 11, 14-cis-eicosatetraenoic acid) is a relevant ω-6 polyunsaturated fatty acid, which plays essential roles in human immune, cardiovascular, and nervous systems. It is widely used ...
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Chapter and Conference Paper
A Study on Forest Flame Recognition of UAV Based on YOLO-V3 Improved Algorithm
In recent years, all regions of China have constantly paid attention to forest fire prevention, which however is still restricted to onsite observation carried out by forest ranger and basic satellite resource...
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Article
Open AccessThe effect of glucocorticoids on serum cystatin C in identifying acute kidney injury: a propensity-matched cohort study
Glucocorticoids may impact the accuracy of serum cystatin C (sCysC) in reflecting renal function. We aimed to assess the effect of glucocorticoids on the performance of sCysC in detecting acute kidney injury (...
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Article
Open AccessC-reactive protein concentration as a risk predictor of mortality in intensive care unit: a multicenter, prospective, observational study
It is not clear whether there are valuable inflammatory markers for prognosis judgment in the intensive care unit (ICU). We therefore conducted a multicenter, prospective, observational study to evaluate the p...
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Article
Open AccessHeavy ion mutagenesis combined with triclosan screening provides a new strategy for improving the arachidonic acid yield in Mortierella alpina
Arachidonic acid (ARA), which is a ω-6 polyunsaturated fatty acid, has a wide range of biological activities and is an essential component of cellular membranes in some human tissues. Mortierella alpina is the be...
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Article
Open AccessExpression of Vitreoscilla hemoglobin enhances production of arachidonic acid and lipids in Mortierella alpina
Arachidonic acid (ARA, C20:4, n-6), which belongs to the omega-6 series of polyunsaturated fatty acids and has a variety of biological activities, is commercially produced in Mortierella alpina. Dissolved oxygen ...
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Article
Open AccessClonal evolution in patients with chronic lymphocytic leukaemia develo** resistance to BTK inhibition
Resistance to the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib has been attributed solely to mutations in BTK and related pathway molecules. Using whole-exome and deep-targeted sequencing, we dissect evolut...
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Article
Open AccessA mix-and-read drop-based in vitro two-hybrid method for screening high-affinity peptide binders
Drop-based microfluidics have recently become a novel tool by providing a stable linkage between phenotype and genotype for high throughput screening. However, use of drop-based microfluidics for screening hig...
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Article
Open AccessLabel-free single-cell protein quantification using a drop-based mix-and-read system
Quantitative protein analysis of single cells is rarely achieved due to technical difficulties of detecting minute amounts of proteins present in one cell. We develop a mix-and-read assay for drop-based label-...
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Article
Electrospun form-stable phase change composite nanofibers consisting of capric acid-based binary fatty acid eutectics and polyethylene terephthalate
The four binary fatty acid eutectics of capric-lauric acid (CA-LA), capric-myristic acid (CA-MA), capric-palmitic acid (CA-PA), and capric-stearic acid (CA-SA) were firstly prepared as solid-liquid phase chang...
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Article
TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy
Embryonic hematopoiesis is a complex process. Elucidating the mechanism regulating hematopoietic differentiation from pluripotent stem cells would allow us to establish a strategy to efficiently generate hemat...
