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Article
Open AccessTime-dependent efficacy analysis of first-line immunotherapies for advanced non–small cell lung cancer
Many randomized controlled trials (RCTs) and network meta-analyses have demonstrated that the progression-free survival (PFS) and overall survival (OS) of advanced non-small cell lung cancer (NSCLC) patients c...
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Article
The mediating role of self-compassion and its components in the relationship between maladaptive perfectionism and life satisfaction among Chinese medical students
Research shows that maladaptive perfectionism as a personality trait can result in a number of mental health problems and lowered life satisfaction levels. Since self-compassion has been demonstrated in numero...
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Article
Open AccessCost-effectiveness of first-line immunotherapy combinations with or without chemotherapy for advanced non–small cell lung cancer: a modelling approach
Many studies have explored the cost-effectiveness of immunotherapy versus chemotherapy alone. However, there is paucity of evidence on direct pharmacoeconomic studies related to immunotherapy combinations. Thu...
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Article
Open AccessAssociations between academic burnout, resilience and life satisfaction among medical students: a three-wave longitudinal study
Research shows that there are connections among academic burnout, resilience, and life satisfaction in medical students. However, no study has yet examined the temporal relationships between academic burnout, ...
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Article
Open AccessAssociations of Chinese diagnosis-related group systems with inpatient expenditures for older people with hip fracture
Hip fracture is frequent in older people and represents a major public health issue worldwide. The increasing incidence of hip fracture and the associated hospitalization costs place a significant economic bur...
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Article
Open AccessSulforaphane induces S-phase arrest and apoptosis via p53-dependent manner in gastric cancer cells
Sulforaphane (SFN) extracted from broccoli sprout has previously been investigated for its potential properties in cancers, however, the underlying mechanisms of the anticancer activity of SFN remain not fully...
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Article
Open AccessAberrant methylation-mediated downregulation of lncRNA CCND2 AS1 promotes cell proliferation in cervical cancer
Long non-coding RNA (lncRNA) plays an important role in tumorigenesis. The lncRNA CCND2 AS1 has been shown to be involved in the growth of several tumors; however, its role in cervical cancer has not been elucida...
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Article
Open AccessEmpathy, burnout, life satisfaction, correlations and associated socio-demographic factors among Chinese undergraduate medical students: an exploratory cross-sectional study
Medical education is widely known to be a demanding process that may cause various mental health problems, such as burnout, which can lead to lowered levels of life satisfaction among medical students. Researc...
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Article
Open AccessCesarean delivery rates, costs and readmission of childbirth in the new cooperative medical scheme after implementation of an episode-based bundled payment (EBP) policy
In the past decade, the rate of cesarean delivery increased dramatically in rural China under the fee-for-service (FFS) system. In September 2011, the New Cooperative Medical Scheme (NCMS) agency in Yong’an co...
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Article
Open AccessEffect of a typical systemic hospital reform on inpatient expenditure for rural population: the Sanming model in China
Considering catastrophic health expenses in rural households with hospitalised members were unproportionally high, in 2013, China developed a model of systemic reform in Sanming by adjusting payment method, ph...
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Article
Open AccessLncRNA UCA1 promotes tumor metastasis by inducing miR-203/ZEB2 axis in gastric cancer
Increasing studies showed that long-noncoding RNAs (lncRNAs) play important roles in the biological processes, including cancer initiation and progression. However, little is known about the exact role and reg...
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Article
Open AccessStudy on the cost attributable to central venous catheter-related bloodstream infection and its influencing factors in a tertiary hospital in China
Central venous catheters (CVC) have been widely used for patients with severe conditions. However, they increase the risk of catheter-related bloodstream infection (CRBSI), which is associated with high econom...
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Article
Open AccessDNA methyltransferase 3A isoform b contributes to repressing E-cadherin through cooperation of DNA methylation and H3K27/H3K9 methylation in EMT-related metastasis of gastric cancer
DNA methyltransferase 3A (DNMT3A) has been recognised as a key element of epigenetic regulation in normal development, and the aberrant regulation of DNMT3A is implicated in multiple types of cancers, especial...
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Article
Open AccessDNA methyltransferase 3A promotes cell proliferation by silencing CDK inhibitor p18INK4C in gastric carcinogenesis
Little is known about the roles of DNA methyltransferase 3A (DNMT3A) in gastric carcinogenesis. Here, we reported that the exogenous expression of DNMT3A promoted gastric cancer (GC) cell proliferation by acce...
