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Article
Optimization Method for Gear Heat Treatment Process Oriented to Deformation and Surface Collaborative Control
Carburizing and quenching can endow the gear with a hardening depth, improving the part's hardness and contact fatigue strength while distorting the part, resulting in increased or uneven subsequent grinding a...
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Article
STAT3 inhibitor BBI608 reduces patient-specific primary cell viability of cervical and endometrial cancer at a clinical-relevant concentration
Aberrant activation of STAT3 signal pathway promotes tumor progression in many solid tumor types, including cervical cancer and endometrial cancer. BBI608, the STAT3 inhibitor had been reported in previous stu...
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Article
Open AccessIdentification of COPA as a potential prognostic biomarker and pharmacological intervention target of cervical cancer by quantitative proteomics and experimental verification
Cervical cancer is the most fatal gynecological carcinoma in the world. It is urgent to explore novel prognostic biomarkers and intervention targets for cervical cancer.
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Article
Open AccessLoading ceftriaxone, vancomycin, and Bifidobacteria bifidum TMC3115 to neonatal mice could differently and consequently affect intestinal microbiota and immunity in adulthood
Recent studies have demonstrated that antibiotics/or probiotics administration in early life play key roles on modulating intestinal microbiota and the alterations might cause long-lasting consequences both ph...
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Article
Association of CYP1A1 polymorphisms with prostate cancer risk: an updated meta-analysis
Epidemiological studies have evaluated the association between 3801T>C and 2455A>G polymorphisms of cytochrome P450 1A1 (CYP1A1) and prostate cancer risk. However, controversy exists regarding the role of thes...
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Article
Increased drug efflux along with midkine gene high expression in childhood B-lineage acute lymphoblastic leukemia cells
Multidrug resistance (MDR) induced by drug efflux has been identified as the major clinical obstacle in the treatment of childhood acute lymphoblastic leukemia (ALL). To explore the possible effects of midkine...