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  1. Article

    Open Access

    Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity

    The crucial role of interferon (IFN) signaling is well known in the restriction or eradication of pathogen invasion. Viruses take a variety of ways to antagonize host defense through eliminating IFN-signaling ...

    Huangcan Li, **ong Wang, Yiran Wang, Yichen Li in Signal Transduction and Targeted Therapy (2023)

  2. No Access

    Article

    Near-infrared-activated anticancer platinum(IV) complexes directly photooxidize biomolecules in an oxygen-independent manner

    Conventional light-driven cancer therapeutics require oxygen and visible light to indirectly damage biomolecules, limiting their efficacy in deep, hypoxic tumours. Here we report the use of near-infrared-activ...

    Zhiqin Deng, Huangcan Li, Shu Chen, Na Wang, Gongyuan Liu, Danjun Liu in Nature Chemistry (2023)

  3. Article

    Open Access

    Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development

    Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER associated stress proteins are molecular chaperones essential for cellular homeostasis. The major functions of HSPs include ch...

    Qianya Wan, Dan Song, Huangcan Li in Signal Transduction and Targeted Therapy (2020)