8 Result(s)

Article

A therapeutic hepatitis B mRNA vaccine with strong immunogenicity and persistent virological suppression

Here we report on the development and comprehensive evaluations of an mRNA vaccine for chronic hepatitis B (CHB) treatment. In two different HBV carrier mouse models generated by viral vector-mediated HBV tran...

Huajun Zhao, **anyu Shao, Yating Yu, Lulu Huang, Narh Philip Amor, Kun Guo… in npj Vaccines (2024)

Article

Correction: Cardioprotective effect of crude polysaccharide fermented by Trametes Sanguinea Lyoyd on doxorubicin-induced myocardial injury mice

Chenjun Shen, Bo Yang, Lili Huang, Yueru Chen… in BMC Pharmacology and Toxicology (2023)

Article

Cardioprotective effect of crude polysaccharide fermented by Trametes Sanguinea Lyoyd on doxorubicin-induced myocardial injury mice

Doxorubicin (DOX) is a broad-spectrum anti-tumor drug, but its clinical application is greatly limited because of the cardiotoxicity. Thus, exploration of effective therapies against DOX-induced cardiotoxicity...

Chenjun Shen, Bo Yang, Lili Huang, Yueru Chen… in BMC Pharmacology and Toxicology (2023)

Article

Sequential acid/reduction response of triblock copolymeric nanomicelles to release camptothecin and toll-like receptor 7/8 agonist for orchestrated chemoimmunotherapy

Immunosuppressive tumor immune microenvironment (TIME) lowers immunotherapy effectiveness. Additionally, low penetration efficiency and unpredictable drug release in tumor areas restrict tumor therapy.

**aoyan Ge, Yanyun Hao, Hui Li, Huajun Zhao, Yang Liu… in Journal of Nanobiotechnology (2022)

Article

Unravelling the enhanced vaccine immunity by heterologous KCONVAC/Ad5-nCoV COVID-19 vaccination

Weijun Zhao, Huajun Zhao, Baoying Huang… in Signal Transduction and Targeted Therapy (2022)

Article

Inhibition of retinoic acid receptor α phosphorylation represses the progression of triple-negative breast cancer via transactivating miR-3074-5p to target DHRS3

Retinoids are promising agents in the treatment of different types of neoplasia including estrogen receptor-positive breast cancers, whereas refractoriness/low sensitivity is observed in triple-negative breast...

Siyue Lou, Hang Gao, Huanwu Hong, Zhihui Zhu… in Journal of Experimental & Clinical Cancer … (2021)

Article

Promotion of epithelial-mesenchymal transformation by hepatocellular carcinoma-educated macrophages through Wnt2b/β-catenin/c-Myc signaling and reprogramming glycolysis

Tumour-associated macrophages (TAMs) in the tumour microenvironment (TME) can promote the progression of hepatocellular carcinoma (HCC). Some tumours can be suppressed by targeting Wnt2b in tumour cells. Howev...

Yu Jiang, Qiuju Han, Huajun Zhao, Jian Zhang in Journal of Experimental & Clinical Cancer … (2021)