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1,381 Result(s)
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Article
Effect of Bricks-and-Mortar Architecture on Fracture Behavior of SiCp/Al Composite: A Finite Element Analysis
The metal-matrix composites (MMCs) with biomimetic bricks-and-mortar architectures have been experimentally demonstrated to exhibit excellent strength-ductility match. Here, biomimetic bricks-and-mortar archit...
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Article
Novel PATL2 variants cause female infertility with oocyte maturation defect
Oocyte maturation defect (OOMD) is a rare cause of in vitro fertilization failure characterized by the production of immature oocytes. Compound heterozygous or homozygous PATL2 mutations have been associated with...
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Article
Open AccessCRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer
Resistance to chemotherapy has been a major hurdle that limits therapeutic benefits for many types of cancer. Here we systematically identify genetic drivers underlying chemoresistance by performing 30 genome-...
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Effectiveness of Lianhua Qingwen Granule and **gyin Gubiao Prescription in Omicron BA.2 Infection and Hospitalization: A Real-World Study of 56,244 Cases in Shanghai, China
To examine the effectiveness of Chinese medicine (CM) Lianhua Qingwen Granule (LHQW) and **gyin Gubiao Prescription (JYGB) in asymptomatic or mild patients with Omicron infection in the shelter hospital.
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Open AccessKinetic nitrogen isotope effects of 18 amino acids degradation during burning processes
Understanding the nitrogen isotopic variations of individual amino acids (AAs) is essential for utilizing the nitrogen isotope values of individual amino acids (δ15N-AA) as source indicators to identify proteinac...
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Article
Genomic structures of insulin-like growth factor from golden pompano (Trachinotus ovatus) and their expression responses to the feed types
Golden pompano is an important aquaculture product in the coastal regions of southern China, which is highly dependent on insulin-like growth factor (IGF) for various biological processes. The cDNAs of ToIGF1, To...
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Open AccessCorrelation between hemoglobin and the risk of common malignant tumors: a 1999–2020 retrospective analysis and causal association analysis
The role of hemoglobin (HGB) in common malignant tumors remains unclear.
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Article
Structural basis of tolvaptan binding to the vasopressin V2 receptor
The vasopressin V2 receptor (V2R) is a validated therapeutic target for autosomal dominant polycystic kidney disease (ADPKD), with tolvaptan being the first FDA-approved antagonist. Herein, we used Gaussian accel...
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Article
Open AccessRadiomic analysis based on magnetic resonance imaging for the prediction of VEGF expression in hepatocellular carcinoma patients
The purpose of this study was to investigate the ability of radiomic characteristics of magnetic resonance images to predict vascular endothelial growth factor (VEGF) expression in hepatocellular carcinoma (HC...
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Article
A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020...
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Open AccessCombined associations of visceral adipose tissue and adherence to a Mediterranean lifestyle with T2D and diabetic microvascular complications among individuals with prediabetes
It’s unclear if excess visceral adipose tissue (VAT) mass in individuals with prediabetes can be countered by adherence to a Mediterranean lifestyle (MEDLIFE). We aimed to examine VAT mass, MEDLIFE adherence, ...
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Open AccessAn intelligent threshold selection method to improve orbital angular momentum-encoded quantum key distribution under turbulence
High-dimensional quantum key distribution (HD-QKD) encoded by orbital angular momentum (OAM) presents significant advantages in terms of information capacity. However, perturbations caused by free-space atmosp...
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Article
Open AccessGastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives
Neuroendocrine neoplasms (NENs) are highly heterogeneous and potentially malignant tumors arising from secretory cells of the neuroendocrine system. Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) a...
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Article
Anti-adipogenesis and anti-obesity potential of alliin mediated by modulating glycolipid metabolism via activating PPARγ signaling
Garlic exhibits hypolipidemic, hypoglycemic, and cardiovascular benefits. The inconsistent results of garlic preparations on adipogenesis have caused more confusion in the public and academia. The compounds re...
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Article
Parameter optimization of the observation system for the South Yellow Sea strong shielding layer based on seismic illumination analysis
The seismic data of the Laoshan Uplift in the South Yellow Sea Basin reveal a low signal-to-noise ratio and low reflection signal energy in the deep Mesozoic–Paleozoic strata. The main reason is that the Mesoz...
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Article
Itemized determination of As, Sb, Bi, Se, and Ge in graphite sample by HG-AFS with high-temperature microwave digestion
In this paper, we optimized a method for fast and accurate determination of five impurity elements (As, Sb, Bi, Se, and Ge) in graphite samples to overcome the shortcomings of existing methods, such as complic...
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Identification and Validation of SLC9A2 as A Potential Tumor Suppressor in Colorectal Cancer: Integrating Bioinformatics Analysis with Experimental Confirmation
To uncover the mechanisms underlying the development of colorectal cancer (CRC), we applied bioinformatic analyses to identify key genes and experimentally validated their possible roles in CRC onset and progr...
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Article
Amorphous NiMo3S13/nickel foam integrated anode for lithium-ion batteries
Although crystalline anode materials with long-range ordered lattice structure are in favor of facilitating the electron transfer, their structures are easily disrupted during long-term cycling due to the cont...
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Article
A PRISMA meta-analysis for diagnostic value of microRNA-21 in head and neck squamous cell carcinoma along with bioinformatics research
The use of miR-21 expression remains vague in diagnosis of head and neck squamous cell carcinoma (HNSCC). This study aimed to systematically evaluate the diagnostic potential of the miR-21 expression in patien...
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Open AccessAssociation of sudden sensorineural hearing loss with meteorological factors: a time series study in Hefei, China, and a literature review
Air pollution can cause disease and has become a major global environmental problem. It is currently believed that air pollution may be related to the progression of SSNHL. As a rapidly develo** city in rece...