-
Article
Open AccessSelective PI3Kδ inhibitor TYM-3-98 suppresses AKT/mTOR/SREBP1-mediated lipogenesis and promotes ferroptosis in KRAS-mutant colorectal cancer
Colorectal cancer (CRC) is one of the most common tumors of the digestive system worldwide. KRAS mutations limit the use of anti-EGFR antibodies in combination with chemotherapy for the treatment of CRC. There...
-
Article
Open AccessAn intelligent threshold selection method to improve orbital angular momentum-encoded quantum key distribution under turbulence
High-dimensional quantum key distribution (HD-QKD) encoded by orbital angular momentum (OAM) presents significant advantages in terms of information capacity. However, perturbations caused by free-space atmosp...
-
Article
Development of Ti–V–Cr–Mn–Mo–Ce high-entropy alloys for high-density hydrogen storage in water bath environments
The V-based body-centered cubic (BCC)-type hydrogen storage alloys have attracted significant attention due to their high theoretical hydrogen storage capacity of 3.80 wt%. However, their practical application...
-
Article
Cutpoints of (1,2) and (2,1) Random Walks on the Lattice of Positive Half Line
In this paper, we study (1,2) and (2,1) random walks in spatially inhomogeneous environments on the lattice of positive half line. We assume that the transition probabilities at site n are asymptotically constant...
-
Article
Open AccessDevelopment of an UPLC-MS/MS method for quantitative analysis of abexinostat levels in rat plasma and application of pharmacokinetics
Broad-spectrum histone deacetylase inhibitors (HDACi) have excellent anti-tumor effects, such as abexinostat, which was a novel oral HDACi that was widely used in clinical treatment. The purpose of this study ...
-
Article
Open AccessAddendum: Cellular differentiation into hyphae and spores in halophilic archaea
-
Article
Left ventricular concentric hypertrophy with cardiac magnetic resonance imaging improves risk stratification in patients with Duchenne muscular dystrophy: a prospective cohort study
The development of left ventricular (LV) remodeling has been associated with an increased cardiovascular risk and cardiogenic death, and different patterns of remodeling result in varying levels of prognosis.
-
Article
Carboxymethyl chitosan promotes biofilm-formation of Cryptococcus laurentii to improve biocontrol efficacy against Penicillium expansum in grapefruit
The synergistic effectiveness of the yeast Cryptococcus laurentii cultured with carboxymethyl chitosan (CMCS) at different concentrations was studied in controlling Penicillium expansum in postharvest grapefruit ...
-
Article
Open AccessAssociations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population
Severe neonatal hyperbilirubinemia could lead to kernicterus and neonatal death. This study aimed to analyze the association between single nucleotide polymorphisms in genes involved in bilirubin metabolism an...
-
Article
Metabolic adaptations of Microbacterium sediminis YLB-01 in deep-sea high-pressure environments
The deep-sea environment is an extremely difficult habitat for microorganisms to survive in due to its intense hydrostatic pressure. However, the mechanisms by which these organisms adapt to such extreme condi...
-
Article
Open AccessTEM1/endosialin/CD248 promotes pathologic scarring and TGF-β activity through its receptor stability in dermal fibroblasts
Pathologic scars, including keloids and hypertrophic scars, represent a common form of exaggerated cutaneous scarring that is difficult to prevent or treat effectively. Additionally, the pathobiology of pathol...
-
Article
Open AccessNeoadjuvant camrelizumab and apatinib combined with chemotherapy versus chemotherapy alone for locally advanced gastric cancer: a multicenter randomized phase 2 trial
Prospective evidence regarding the combination of programmed cell death (PD)−1 and angiogenesis inhibitors in treating locally advanced gastric cancer (LAGC) is limited. In this multicenter, randomized, phase ...
-
Article
Investigation on the impact of low atmospheric pressure on bubble stability in cement-based materials
With more infrastructures being built in high-altitude regions, the impact of low atmospheric pressure on the stability of air bubbles in cementitious materials has aroused extensive attention. However, its in...
-
Article
Open AccessParticle-associated denitrification is the primary source of N2O in oxic coastal waters
The heavily human-perturbed coastal oceans are hotspots of nitrous oxide (N2O) emission to the atmosphere. The processes underpinning the N2O flux, however, remain poorly understood, leading to large uncertaintie...
-
Article
Open AccessDerivation and validation of diagnostic models for myocardial fibrosis in duchenne muscular dystrophy: assessed by multi-parameter cardiovascular magnetic resonance
Gadolinium-enhanced cardiovascular magnetic resonance (CMR) is the most widely used approach for diagnosing myocardial fibrosis with late gadolinium enhancement (LGE) in cardiomyopathy associated with Duchenne...
-
Article
The analyses of the complete mitochondrial genomes of three crabs revealed novel gene rearrangements and phylogenetic relationships of Brachyura
Brachyura crab is the largest branch of Decapoda crustacean. Phylogenetic relationships within Brachyura remain controversial to be investigated. The mitochondrial genome (mitogenome) is an important molecular...
-
Article
Open AccessLongitudinal changes in magnetic resonance imaging biomarkers of the gluteal muscle groups and functional ability in Duchenne muscular dystrophy: a 12-month cohort study
Quantitative magnetic resonance imaging (MRI) is considered an objective biomarker of Duchenne muscular dystrophy (DMD), but the longitudinal progression of MRI biomarkers in gluteal muscle groups and their pr...
-
Article
Study on removal of recast layer of NiTi shape memory alloy machined with magnetic field-assisted WEDM-ECM complex process
In this paper, a magnetic field-assisted WEDM-ECM complex process (MF-assisted WEDM-ECM) is proposed to solve the problems of traditional low-speed wire electrical discharge machining (WEDM-LS) of NiTi SMA, in...
-
Article
CDK6 is a novel predictive and prognosis biomarker correlated with immune infiltrates in multiple human neoplasms, including small cell lung carcinoma
The roles of cyclin-dependent kinase 6 (CDK6) in various cancers, including small cell lung carcinoma (SCLC), remain unclear. Here, 111,54 multi-center samples were investigated to determine the expression, clini...
-
Article
ITGB4 Serves as an Identification and Prognosis Marker Associated with Immune Infiltration in Small Cell Lung Carcinoma
Integrin beta 4 (ITGB4) is a vital factor for numerous cancers. However, no reports regarding ITGB4 in small cell lung carcinoma (SCLC) have been found in the existing literature. This study systematically invest...
