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Article
Open AccessMitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype
Bacterial genotoxins damage host cells by targeting their chromosomal DNA. In the present study, we demonstrate that a genotoxin of Salmonella Typhi, typhoid toxin, triggers the senescence-associated secretory ph...
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Article
Open AccessINPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control
The immune synapse, a highly organized structure formed at the interface between T lymphocytes and antigen-presenting cells (APCs), is essential for T cell activation and the adaptive immune response. It has b...
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Article
Open AccessEpigenetic remodeling of the immune landscape in cancer: therapeutic hurdles and opportunities
The tumor immune microenvironment represents a sophisticated ecosystem where various immune cell subtypes communicate with cancer cells and stromal cells. The dynamic cellular composition and functional charac...
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Article
Open AccessTransforming growth factor-β1 decreases erythropoietin production through repressing hypoxia-inducible factor 2α in erythropoietin-producing cells
Renal erythropoietin (EPO)-producing (REP) cells produce EPO through hypoxia-inducible factor (HIF) 2α-activated gene transcription. Insufficient EPO production leads to anemia in patients with chronic kidney ...
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Article
Open AccessEpigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer
γδ T cells are a distinct subgroup of T cells that bridge the innate and adaptive immune system and can attack cancer cells in an MHC-unrestricted manner. Trials of adoptive γδ T cell transfer in solid tumors ...
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Article
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons
Optogenetic induction of phasic, but not tonic, firing in VTA dopamine neurons induces susceptibility to stress in mice undergoing a subthreshold social-defeat paradigm and in previously resilient mice that ha...
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Article
Dopamine neurons modulate neural encoding and expression of depression-related behaviour
Specific manipulation of midbrain dopamine neurons in freely moving rodents shows that their inhibition or excitation immediately modulates depression-like phenotypes that are induced by chronic mild stress, a...
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Article
Cancer epigenetics: linking basic biology to clinical medicine
Cancer evolution at all stages is driven by both epigenetic abnormalities as well as genetic alterations. Dysregulation of epigenetic control events may lead to abnormal patterns of DNA methylation and chromat...
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Article
Induction of inducible nitric oxide synthase by Epstein-Barr virus B95-8-derived LMP1 in Balb/3T3 cells promotes stress-induced cell death and impairs LMP1-mediated transformation
The latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) causes cellular transformation and activation of several intracellular signaling events. In this report, we show that BLMP1 (encoded by the LMP1...
