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Article
Open AccessDirected biomechanical compressive forces enhance fusion efficiency in model placental trophoblast cultures
The syncytiotrophoblast is a multinucleated structure that arises from fusion of mononucleated cytotrophoblasts, to sheath the placental villi and regulate transport across the maternal–fetal interface. Here, ...
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Article
Open AccessEpidermolysis Bullosa: Two rare case reports of COL7A1 and EBS-GEN SEV KRT14 variants with review of literature
Bullosa is a rare hereditary skin condition that causes blisters. Genes encoding structural proteins at or near the dermal-epidermal junction are mutated recessively or dominantly, and this is the primary caus...
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Article
Open AccessUnraveling the mediation role of frailty and depression in the relationship between social support and self-management among Chinese elderly COPD patients: a cross-sectional study
Self-management (SM) is the key factor in controlling the progression of chronic obstructive pulmonary disease (COPD). Previous studies have reported that majority of COPD patients later presented with frailty...
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Article
Open AccessA high-resolution time-variable terrestrial gravity field model of continental North China
Given the spatial resolution of ~300 km in Gravity Recovery and Climate Experiment (GRACE) measurements, accurately quantifying mass variations at smaller scales proves challenging. Here, we present a high-res...
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Article
Open AccessIRF4 affects the protective effect of regulatory T cells on the pulmonary vasculature of a bronchopulmonary dysplasia mouse model by regulating FOXP3
Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in preterm infants, characterised by compromised alveolar development and pulmonary vascular abnormalities. Emerging evidence suggests that reg...
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Chapter
Definitions and a Review of Relevant Theories, Frameworks, and Approaches
This chapter focuses on a review of the literature on the theories, frameworks, and approaches that inform teacher professional development in vocational education. We first define the scope of vocational educ...
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Article
Open AccessA novel internet sampling for HIV surveillance: feasibility of self-sampling and preparation of DBS for delivery detection of HIV total nucleic acid and complementarity to sentinel surveillance
To propose a new mode of HIV test and surveillance among population of men who have sex with men (MSM): Internet-based Self-sampling at home plus Laboratory testing of HIV total nucleic acid (TNA) in dried blo...
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Article
Open AccessEffect of PI3K/AKT/mTOR signaling pathway-based clustered nursing care combined with papaverine injection on vascular inflammation and vascular crisis after replantation of severed fingers
This research aimed to investigate the effect of PI3K (phosphatidylinositol 3-kinase)/AKT (protein kinase B)/mTOR (mammalian target protein of rapamycin) signaling pathway-based clustering care combined with p...
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Article
Open AccessILC2 regulates hyperoxia-induced lung injury via an enhanced Th17 cell response in the BPD mouse model
Recent research has focused on the role of immune cells and immune responses in the pathogenesis of bronchopulmonary dysplasia (BPD), but the exact mechanisms have not yet been elucidated. Previously, the key ...
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Article
Open AccessBehavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern China
Previous studies have not clearly demonstrated the impact of behavioral and emotional problems (BEDs) on treatment outcomes among HIV-infected children on antiretroviral therapy (ART). This study aimed to desc...
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Article
Open AccessComparison of gut viral communities in children under 5 years old and newborns
The gut virome of humans is mainly composed of bacteriophages and their role in sha** the gut microbiome and influencing human health is increasingly recognized. However, little is known about the dynamic ch...
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Article
Open AccessAwareness and use of HIV pre-exposure prophylaxis and factors associated with awareness among MSM in Bei**g, China
Human immunodeficiency virus (HIV) sexual transmission among men who have sex with men (MSM) has increased markedly in Bei**g, China in the past decade. Pre-exposure prophylaxis (PrEP) is a highly efficacious...
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Article
Open AccessPrediction of 30-day risk of acute exacerbation of readmission in elderly patients with COPD based on support vector machine model
Acute exacerbation of chronic obstructive pulmonary disease (COPD) is an important event in the process of disease management. Early identification of high-risk groups for readmission and appropriate measures ...
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Article
Open AccessDynamic Changes of NCR− Type 3 Innate Lymphoid Cells and Their Role in Mice with Bronchopulmonary Dysplasia
Inflammation is one of the important pathogenesis of bronchopulmonary dysplasia (BPD). Type 3 innate lymphoid cells (ILC3) play a role in a variety of inflammatory lung diseases. In this study, we established ...
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Article
Open AccessCRF07_BC is associated with slow HIV disease progression in Chinese patients
HIV subtypes convey important epidemiological information and possibly influence the rate of disease progression. In this study, HIV disease progression in patients infected with CRF01_AE, CRF07_BC, and subtyp...
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Article
Open AccessThe function role of ubiquitin proteasome pathway in the ER stress-induced AECII apoptosis during hyperoxia exposure
Bronchopulmonary dysplasia (BPD) is a major cause of mortality and morbidity in premature infants, characterized by alveolar dysplasia and pulmonary microvascular remodeling. In the present study, we have inve...
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Article
Open AccessExpression profiles, biological functions and clinical significance of circRNAs in bladder cancer
Circular RNAs (circRNAs), which are single-stranded closed-loop RNA molecules lacking terminal 5′ caps and 3′ poly(A) tails, are attracting increasing scientific attention for their crucial regulatory roles in...
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Article
Open AccessGeneration of plane spiral orbital angular momentum using circular double-slot Vivaldi antenna array
A novel and feasible solution to generate plane spiral orbital angular momentum (PSOAM) vortex beam is proposed in this paper. The general principle of generating PSOAM in circular antenna array (CAA) is deduc...
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Article
Open AccessUnderstanding the molecular association between hyperkalemia and lung squamous cell carcinomas
Previous studies indicated a strong association between hyperkalemia and lung squamous cell carcinomas (LSCC). However, the underlying mechanism is not fully understood so far.
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Article
Open AccessEffects of C/EBPα overexpression on alveolar epithelial type II cell proliferation, apoptosis and surfactant protein-C expression after exposure to hyperoxia
This study aims to investigate the effects of CCAAT/enhancer binding protein alpha (C/EBPα) overexpression on cell proliferation, apoptosis and surfactant protein-C(SP-C) in alveolar epithelial type II (AEC II...
