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    Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase

    Reductive desymmetrization of 2,2-disubstituted prochiral 1,3-cyclodiketones to 2,2-disubstituted-3-hydroxycycloketones is a highly desired transformation for the construction of complex molecules with multipl...

    ** Chen, Hongliu Zhang, Miguel A. Maria-Solano, Weidong Liu, Juan Li… in Nature Catalysis (2019)