-
Article
Effects of Na2O and CaCl2 on the Crystallization and Mechanical Properties of CaO-MgO-Al2O3-SiO2 Glass–Ceramics
In this paper, we respectively added 5 wt% of Na2O and CaCl2 to the CaO–MgO–Al2O3–SiO2 base glass, aiming to analyze the effect of the types of flux, CaCl2, and traditional flux Na2O, on the crystallization behav...
-
Article
Preparation of Ni–Fe–S Matte and Fe–Cr–Si Alloy by the Co-treatments of Stainless Steel Pickling Sludge and Electroplating Sludge
In this work, stainless steel pickling sludge (SSPS) and Ni-bearing electroplating sludge (ES) were co-treated to prepare Ni matte and Fe–Cr–Si alloy. A two-stage sulfurization-smelting method was used for pre...
-
Article
Skullcapflavone II, a novel NQO1 inhibitor, alleviates aristolochic acid I-induced liver and kidney injury in mice
Aristolochic acid I (AAI) is a well established nephrotoxin and human carcinogen. Cytosolic NAD(P)H quinone oxidoreductase 1 (NQO1) plays an important role in the nitro reduction of aristolochic acids, leading...
-
Article
Preparation of Ferrosilicochromium by Silicothermic Reduction of Cr-Bearing Electroplating Sludge
In this study, a novel process for recovering Cr from Cr-bearing electroplating sludge (ES) was proposed, which involved the desulfurization stage and reduction-smelting stage. In the desulfurization stage, th...
-
Article
Open AccessThe development of a cSMART-based integrated model for hepatocellular carcinoma diagnosis
Hepatocellular carcinoma (HCC) generally arises from a background of liver cirrhosis (LC). Patients with cirrhosis and suspected HCC are recommended to undergo serum biomarker tests and imaging diagnostic eval...
-
Article
The Alkaline Leaching Behavior of Silica Solid Solutions in the Product Obtained by Roasting the Mixture of High-Alumina Coal Gangue and Hematite
A novel technology of hematite involved roasting-alkaline leaching-Bayer digestion process was proposed to extract alumina from high-alumina coal gangue (HACG), however the resource utilization of silica was n...
-
Article
Hepatocyte-derived VEGFA accelerates the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma via activating hepatic stellate cells
Non-alcoholic fatty liver disease (NAFLD) is emerging as an epidemic risk factor for hepatocellular carcinoma (HCC). The progression of NAFLD to HCC is closely associated with paracrine communication among hep...
-
Article
Preparation of Ni–Fe–S Matte from Nickeliferous Laterite Ore Using CaS as the Sulfurization Agent
In the present work, a novel method of producing Ni–Fe–S matte from saprolite type laterite (SL) ores was proposed using CaS as the sulfurization agent at 1500 °C under Ar atmosphere. The prepared Ni–Fe–S matt...
-
Article
Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein
An epidemic of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading worldwide. SARS-CoV-2 relies on its spike protein to invade host cells by interacting with the human...
-
Article
Review of electrochemical degradation of phenolic compounds
Phenolic compounds are widely present in domestic and industrial sewage and have serious environmental hazards. Electrochemical oxidation (EO) is one of the most promising methods for sewage degradation becaus...
-
Article
Genetic Susceptibility Study of Chinese Sudden Sensorineural Hearing Loss Patients with Vertigo
To investigate the genetic causes of sudden sensorineural hearing loss (SSNHL) patients in China. This study focused on analyzing variations of coding sequence of common genes related to deafness, revealing th...
-
Article
Open AccessGenome-scale profiling of circulating cell-free DNA signatures for early detection of hepatocellular carcinoma in cirrhotic patients
-
Article
Identification of important genes and drug repurposing based on clinical-centered analysis across human cancers
Identification of the functional impact of mutated and altered genes in cancer is critical for implementing precision oncology and drug repurposing. In recent years, the emergence of multiomics data from large...
-
Article
Preparation of Low-Carbon and Low-Sulfur Fe-Cr-Ni-Si Alloy by Using CaSO4-Containing Stainless Steel Pickling Sludge
Stainless steel pickling sludge is the precipitate from the neutralization process of stainless steel pickling liquor. Until now, many methods about the harmless treatments of pickling sludge have been develop...
-
Article
Effect of adhesive on laser-arc hybrid welding of aluminum alloy to high-strength steel joint
Aluminum alloy 6061 and high-strength steel Q460 were joined by laser-arc-adhesive hybrid welding technology successfully. A Cu alloy interlayer was added between Al alloy and high-strength steel. The effect o...
-
Article
Microstructural and mechanical properties of ZA10 alloy tubes and their weld seams prepared by Conform continuous extrusion
In the present work, Zn–10Al–2Cu–0.05Ti (ZA10) alloy tubes with a diameter of 12.5 mm and wall thickness of 1.2 mm were fabricated by one-pass and double-pass Conform continuous extrusion. A stabilizing heat t...
-
Article
Open AccessER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome that elevates the risk of hepatocellular carcinoma (HCC). Although alteration of lipid metabolism has been incre...
-
Article
Open AccessImmune contexture defined by single cell technology for prognosis prediction and immunotherapy guidance in cancer
Tumor immune microenvironment is closely related to tumor initiation, prognosis, and response to immunotherapy. The immune landscapes, number of infiltrating immune cells, and the localization of lymphocytes i...
-
Article
Open AccessExpansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens
The study of pathophysiological mechanisms in human liver disease has been constrained by the inability to expand primary hepatocytes in vitro while maintaining proliferative capacity and metabolic function. W...
-
Article
Numerical simulation for pulsed laser–gas tungsten arc hybrid welding of magnesium alloy
Based on the extended application of COMSOL multiphysics, a novel dual heat source model for pulsed laser–gas tungsten arc (GTA) hybrid welding was established. This model successfully solved the problem of si...
