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Article
Aberrant Histone Modification of TNFAIP3, TLR4, TNIP2, miR-146a, and miR-155 in Major Depressive Disorder
Activated toll-like receptor (TLR) signaling has been well investigated in major depressive disorder (MDD). We previously reported that TNFAIP3, TLR4, TNIP2, miR-146a, and miR-155 play important roles in regu...
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Article
Open AccessTargeted activation of androgen receptor signaling in the periosteum improves bone fracture repair
Low testosterone level is an independent predictor of osteoporotic fracture in elderly men as well as increased fracture risk in men undergoing androgen deprivation. Androgens and androgen receptor (AR) action...
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Article
Open AccessLimited relationships between reactive oxygen species levels in culture media and zygote and embryo development
Reactive oxygen species (ROS) are thought to play a critical role in the success of IVF. The relationships between oxidative stress parameters in culture media and IVF outcomes have not been extensively invest...
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Article
Open AccessAntidepressants normalize elevated Toll-like receptor profile in major depressive disorder
Abnormalities in Toll-like receptor (TLR) expression in depression have been inferred in part from observed increases in TLR4 levels in peripheral blood mononuclear cells (PBMCs) and postmortem brains of depre...
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Article
Establishment and characterization of an experimental mouse model of allergic rhinitis
Allergic rhinitis (AR) is a common worldwide disease. Animal studies on AR were adopted in various investigations. However, animal studies simply aimed at establishing an animal model for AR have been seldom s...
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Article
MicroRNA-21 regulates stemness in cancer cells
MicroRNA-21 (miR-21) functions have been linked to cancer progression and chemo- or radiotherapy resistance. While an increasing number of studies have reported a potential role of miR-21 expression in promoti...
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Article
Open AccessAnalysis of androgen receptor and anti-Müllerian hormone pathways in human granulosa cells under luteinizing hormone treatment
The objective of this study was to determine the gene expression profiles of the androgen/androgen receptor (AR) and anti-Müllerian hormone (AMH)/ Sry-related high-mobility group box 9 (SOX9) pathways in granu...
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Article
Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis
A complex containing the oncogene Myc, Skp2 E3 ligase and the coactivators Miz1 and p300 promotes transcription of RhoA. Overexpression of this complex increases RhoA levels and is detected in metastatic human ca...
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Article
Expression of inhibin-activin subunits, follistatin and smads in granulosa-luteal cells collected at oocyte retrieval
Purpose: To examine the expression of inhibin-activin subunits, follistatin, and Smads 2, 3 and 4 in granulosa-luteal cells at the time of oocyte retrieval.
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Article
Differential induction of androgen receptor transactivation by different androgen receptor coativators in human prostate cancer DU 145 cells
Recently identified androgen receptor (AR) coactivators were used in this study to determine whether the specificity of sex hormones and antiandrogens could be modulated at the coactivator level. We found that...
