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Article
Open AccessId1 induces apoptosis through inhibition of RORgammat expression
Basic helix-loop-helix E proteins are transcription factors that play crucial roles in T cell development by controlling thymocyte proliferation, differentiation and survival. E protein functions can be repres...
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Article
Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase
To investigate whether resveratrol (RSV) can improve non-alcoholic fatty liver disease (NAFLD) and to find the possible mechanism.
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Article
Open AccessExploring transcriptional signalling mediated by OsWRKY13, a potential regulator of multiple physiological processes in rice
Rice transcription regulator OsWRKY13 influences the functioning of more than 500 genes in multiple signalling pathways, with roles in disease resistance, redox homeostasis, abiotic stress responses, and devel...
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Article
Open AccessSpontaneous regression of advanced hepatocellular carcinoma: a case report
Spontaneous regression of advanced hepatocellular carcinoma is extremely rare. A 66-year-old Taiwanese male patient with liver cirrhosis related to chronic hepatitis C presented with hepatocellular carcinoma w...
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Open AccessHepatoid adenocarcinoma of the stomach with liver metastasis mimicking hepatocellular carcinoma: a case report
Hepatoid adenocarcinoma is a special type of extrahepatic alpha-fetoprotein-producing adenocarcinoma, which has a morphologic similarity to hepatocellular carcinoma. We report a patient with underlying hepatit...
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Article
Open AccessMRP2 and GSTP1 polymorphisms and chemotherapy response in advanced non-small cell lung cancer
The level of drug metabolism and drug transport is correlated with the sensitivity of cancer cells towards platinum-based chemotherapy. We hypothesize that genetic polymorphisms in metabolising enzymes gene GS...
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Article
Gemcitabine combined with gum mastic causes potent growth inhibition and apoptosis of pancreatic cancer cells
To investigate the antiproliferative and apoptotic effects of gemcitabine combined with gum mastic and the underlying mechanisms in human pancreatic cancer cell lines.
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Open AccessThe common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Bei**g, China
Previous genome-wide association studies for type 2 diabetes susceptibility genes have confirmed that a common variant, rs9939609, in the fat mass and obesity associated (FTO) gene region is associated with body ...
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Article
Open AccessModulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke
The relationship between functional improvements in ischemic rats given a neural stem cell (NSC) transplant and the modulation of the class I major histocompatibility complex (MHC) mediated by NSC-derived neur...
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Article
Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes
Notch signaling controls multiple developmental processes, thus demanding versatile functions. We have previously shown that this may be partly achieved by accelerating ubiquitin-mediated degradation of import...
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Article
Open AccessHigh lake levels on Alxa Plateau during the Late Quaternary
Field investigations including lake shoreline measurement and 14C chronology have been carried out on the Alxa Plateau to better understand the formation and evolution of the high lake levels in northwest China d...
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Article
Open AccessDetection of HBV Genotypes of Tumor Tissues and Serum by A Fluorescence Polarization Assay in North-Western China's Hepatocellular Carcinoma Patients
The understanding of the distribution of hepatitis B virus genotypes and the occult hepatitis B virus infection in hepatocellular carcinoma may shed light into the prevention and treatment of hepatocellular ca...
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Article
Open AccessNuclear beta-catenin overexpression in metastatic sentinel lymph node is associated with synchronous liver metastasis in colorectal cancer
Beta-catenin, a component of the Wingless/Wnt signaling pathway, can activate target genes linking with the adenomatous polyposis coli (APC) gene in colorectal cancer. The purpose of this study is to investiga...
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Open AccessHomoepitaxial regrowth habits of ZnO nanowire arrays
Synthetic regrowth of ZnO nanowires [NWs] under a similar chemical vapor transport and condensation [CVTC] process can produce abundant ZnO nanostructures which are not possible by a single CVTC step. In this ...
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Open AccessComparative analyses reveal potential uses of Brachypodium distachyonas a model for cold stress responses in temperate grasses
Little is known about the potential of Brachypodium distachyon as a model for low temperature stress responses in Pooideae. The ice recrystallization inhibition protein (IRIP) genes, fructosyltransferase (FST) ge...
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Article
Open AccessTreatment of one case of cerebral palsy combined with posterior visual pathway injury using autologous bone marrow mesenchymal stem cells
Cerebral palsy is currently one of the major diseases that cause severe paralysis of the nervous system in children; approximately 9–30% of cerebral palsy patients are also visually impaired, for which no effe...
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Article
Open AccessQuantitative criteria for improving performance of buccal DNA for high-throughput genetic analysis
DNA from buccal brush samples is being used for high-throughput analyses in a variety of applications, but the impact of sample type on genoty** success and downstream statistical analysis remains unclear. T...
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Article
Coverage-based search result diversification
Traditional retrieval models may provide users with less satisfactory search experience because documents are scored independently and the top ranked documents often contain excessively redundant information. ...
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Open AccessPrevalence of metabolic syndrome in a cohort of Chinese schoolchildren: comparison of two definitions and assessment of adipokines as components by factor analysis
Although attention to metabolic syndrome (MetS) in children has increased, there is still no universally accepted definition and its pathogenesis remains unclear. Our aim was to compare the current definitions...
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Open AccessDraft genome sequence of Amphibacillus jilinensis Y1T, a facultatively anaerobic, alkaliphilic and halotolerant bacterium
The genus Amphibacillus was established in 1990, and seven additional species were described in the past two decades. Amphibacillus jilinensis Y1T is a facultatively anaerobic and alkaliphilic bacterium isolated ...
