57 Result(s)
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Article
Fossil embryos from the Middle and Late Cambrian period of Hunan, south China
Comparative embryology is integral to uncovering the pattern and process of metazoan phylogeny1, but it relies on the assumption that life histories of living taxa are representative of their antecedents. Fossil ...
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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
The stability of the Wnt pathway transcription factor β-catenin is tightly regulated by the multi-subunit destruction complex. Deregulated Wnt pathway activity has been implicated in many cancers, making this ...
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Open AccessMesoscopic Interactions and Species Coexistence in Evolutionary Game Dynamics of Cyclic Competitions
Evolutionary dynamical models for cyclic competitions of three species (e.g., rock, paper and scissors, or RPS) provide a paradigm, at the microscopic level of individual interactions, to address many issues i...
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Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution
Deep-genome and single-cell sequencing analyses of patient-derived breast cancer xenografts reveal extensive, dynamic and reproducible changes in intra-tumoral mutational clonal composition on engraftment and ...
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Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages
NDR/LATS kinase family is highly conserved from yeast to human. It remains unknown whether the members of this family function in innate immune responses. Here we demonstrate that Stk38 negatively regulates TL...
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Open AccessArsenic profile distribution of the wetland argialbolls in the Sanjiang plain of northeastern China
The wetland Argialbolls pedon was chosen to investigate the effects of pedogenic processes and anthropogenic activities on the vertical distribution of As concentrations. Two wetland Argialboll cores (90 cm lo...
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Open AccessRecombinant human endostatin enhances the radioresponse in esophageal squamous cell carcinoma by normalizing tumor vasculature and reducing hypoxia
The aim of this study was to investigate the effect of recombinant human endostatin (rh-Endo) in combination with radiation therapy (RT) on esophageal squamous cell carcinoma (ESCC) and explore the potential m...
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Open AccessFamily history of esophageal cancer increases the risk of esophageal squamous cell carcinoma
A population-based case-control was performed to explore familial aggregation of esophageal squamous cell carcinoma (ESCC). Family history of cancer was assessed by a structured questionnaire and from which 2 ...
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Open AccessZyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways
The evolutionarily conserved Hippo pathway is a regulator that controls organ size, cell growth and tissue homeostasis. Upstream signals of the Hippo pathway have been widely studied, but how microenvironmenta...
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Open AccessAntibiofilm effect enhanced by modification of 1,2,3-triazole and palladium nanoparticles on polysulfone membranes
Biofouling impedes the performance of membrane bioreactors. In this study, we investigated the antifouling effects of polysulfone membranes that were modified by 1,2,3-triazole and palladium (Pd) nanoparticles...
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Open AccessAbrupt sand-dune accumulation at the northeastern margin of the Tibetan Plateau challenges the wet MIS3a inferred from numerous lake-highstands
Over the Tibetan Plateau and adjacent regions, numerous 14C-based lake records revealed a ubiquitous wet climatic period during 40–25 ka (late MIS 3), which is in contradiction with the global pattern of generall...
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Open AccessCell-based phenotypic screening of mast cell degranulation unveils kinetic perturbations of agents targeting phosphorylation
Mast cells play an essential role in initiating allergic diseases. The activation of mast cells are controlled by a complicated signal network of reversible phosphorylation and finding the key regulators invol...
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Open AccessSynthesis of Vertically Standing MoS2 Triangles on SiC
Layered material MoS2 has been attracting much attention due to its excellent electronical properties and catalytic property. Here we report the synthesis of vertically standing MoS2 triangles on silicon carbon(S...
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Open AccessDecreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream
The subventricular zone (SVZ) provides a constant supply of new neurons to the olfactory bulb (OB). Different studies have investigated the role of olfactory sensory input to neural precursor cell (NPC) turnov...
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Open AccessIdentification of BnaYUCCA6 as a candidate gene for branch angle in Brassica napus by QTL-seq
Oilseed rape (Brassica napus L.) is one of the most important oil crops in China as well as worldwide. Branch angle as a plant architecture component trait plays an important role for high density planting and yi...
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Open AccessA nationwide cross-sectional survey on prevalence, management and pharmacoepidemiology patterns on hypertension in Chinese patients with chronic kidney disease
Limited data are available on epidemiology and drug use in Chinese hypertensive patients with chronic kidney disease (CKD). We determined the prevalence; awareness, treatment, and control rates of hypertension...
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Open AccessTargeting to the non-genomic activity of retinoic acid receptor-gamma by acacetin in hepatocellular carcinoma
We recently demonstrated that retinoic acid receptor-γ (RARγ) is overexpressed and acts as a tumor promoter in hepatocellular carcinoma (HCC). The oncogenic activity of RARγ is mainly attributed to its physiol...
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Open AccessImpact of genotype on endocrinal complications of Children with Alpha-thalassemia in China
Alpha-thalassemia occurs with high frenquency in China. Four common α-globin gene deletion mutations (–SEA, -α3.7, and -α4.2, Haemoglobin Constant Spring (CS) mutation) were identified in Chinese patients. Ind...
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Open AccessIn–situ XRD and EDS method study on the oxidation behaviour of Ni–Cu sulphide ore
The oxidation mechanism of sulfides is the key issue during the sulphide–metallurgy process. In this study, the phase transformation and element migration were clearly demonstrated by in–situ laboratory–based ...
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Open AccessKey driving forces of desertification in the Mu Us Desert, China
The temporal trends and key driving forces of desertification in the Mu Us Desert are representatives of most arid regions of Asia with a high risk of desertification. We analyzed the significance of Aeolian t...
