19 Result(s)
within
Hong** Wei
Inorganic Chemistry
Nuclear Physics, Heavy Ions, Hadrons
Physical Chemistry
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Article
Comparative cytotoxicity of 177Lu on various lung cancer cells and in vivo targeting of 177Lu-labeled cetuximab
Differences in cellular radiosensitivity and the binding affinity of radiopharmaceuticals could directly affect the radiotherapeutic effects. In this study, we investigated the radionuclide (177Lu) induced radios...
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Article
Evaluation of [99mTc]Tc-TTHMP as a SPECT imaging agent for skeletal system
TTHMP (triethylene-tetramine-hexamethylene-phosphonic acid) shows good bone-seeking ability in previous studies. In this research, [99mTc]Tc-TTHMP was prepared with the radiochemical yield of 98% and the possibl...
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Article
Effective lutetium/ytterbium separation for no-carrier added lutetium-177 production
In order to realize no-carrier added lutetium-177 (177Lu) production through 176Yb(n, γ) 177Yb→ 177Lu process, effective separation of 177Lu from Yb target including lanthanide resin (LNR) and high performance li...
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Article
Preliminary evaluation and in vitro cytotoxicity studies of [131I]I-trastuzumab in HER2 expressing ovarian cancer cells
As trastuzumab is known to target the human epidermal growth factor receptor type (HER2), the potential of [131I]I-trastuzumab as a radioimmunotherapy agent was evaluated in vitro and in vivo for HER2-overexpress...
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Article
In vitro and in vivo evaluation of a novel anti-EGFR antibody labeled with 89Zr and 177Lu
There is an urgent need to develop more specific targeted therapies for lung cancer treatment due to the its low survival rate. EGFR is a transmembrane tyrosine kinase protein that is overexpressed in lung can...
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Article
89Zr and 177Lu labeling of anti-DR5 monoclonal antibody for colorectal cancer targeting PET-imaging and radiotherapy
Death receptor 5 (DR5) is overexpressed in many tumors. Combination of the anti-DR5 antibody with radionuclides such as lutetium-177 (177Lu) could enhance apoptosis and decrease the possibility of drug-induced re...
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Article
Preparation and cellular-interaction investigation of 177Lu/FITC labeled NGR peptides
Aminopeptidase N (CD13) as the malignant cell surface marker is overexpressed on many tumor cells including lung cancer and the neovascular cell membranes. A tripeptide structure, Asn-Gly-Arg (NGR), can specif...
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Article
Removal of uranium by biogenetic jarosite coupled with photoinduced reduction in the presence of oxalic acid: a low-cost remediation technology
As jarosite and oxalic acid are ubiquitous in nature, we investigated a remediation technology for uranium-contaminated site by photoinduced reduction coupled with adsorption of jarosite. Jarosite exhibited ex...
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Article
Synergistic effects of electron shuttle AQS and Alcaligenes faecalis on photocatalytic removal of U(VI)
Photocatalytic removal of U(VI) has attracted much attention due to its advantages such as no secondary pollution and less energy consumption. Synergistic removal of U(VI) by Alcaligenes faecalis and exogenous el...
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Article
Comparative cell uptake study of FITC-/177Lu-labeled RM26 monomer, dimer and trimer on PC-3: improving binding affinity of gastrin releasing peptide receptor (GRPR) antagonist via bivalency/trivalency
The gastrin releasing peptide receptors (GRPRs) overexpress in various tumors, which provided the opportunity for GRPR targeted tumor radiological diagnosis and therapy. In recent reports, the GPPR antagonists...
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Article
131I-labeled PEG and folic acid co-functionalized graphene quantum dots for tumor-targeted imaging
In this study, we successfully synthesized polyethylene glycol (PEG) and folic acid (FA) co-functionalized graphene quantum dots (GQDs) to improve the biocompatibility and tumor-targeting ability of GQDs simul...
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Article
Binding and cytotoxicity of 131I-labeled gastrin-releasing peptide receptor antagonists modified by cell penetrating peptides
Gastrin releasing peptide receptors (GRPRs) are one of the most interesting targets over expressed in various tumors. Due to the superior potential of the GRPR antagonist analogs, they have been studied in the...
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Article
Characteristics and mechanism of uranium photocatalytic removal enhanced by chelating hole scavenger citric acid in a TiO2 suspension system
Polycarboxylic acid acts as hole scavenger and chelating agent, which is essential for the photocatalytic removal of multivalent metal ions. The photocatalytic uranium removal, role of chelating hole scavenger...
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Article
Preparation and biodistribution of 131I-labeled graphene quantum dots
For the superiority of graphene quantum dots (GQDs) in bioimaging and drug delivery carrier, GQDs bring new opportunities for theranostics of diseases. In this study, GQDs were successfully prepared and labele...
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Article
131I-labeled 5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin and 5,10,15,20-tetrakis(4-aminophenyl)porphyrin for combined photodynamic and radionuclide therapy
Porphyrin derivatives are usually used for photodynamic therapy (PDT) and labeled with raidonuclide for radiopharmaceuticals. In this work, 5,10,15,20-tetrakis (4-hydroxyphenyl) porphyrin (TPPOH) and 5,10,15,2...
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Article
Effective way to radiolabel the peptide of MAG3–RM26 with 188Re and the study on its coordination chemistry
The antagonist of gastrin releasing peptide RM26 conjugated with MAG3 (Ac-MAG3-Gly-Gly-Gly-AEEA-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2) was labelled with 188Re and 186Re. LC–MS was used to propose the structur...
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Article
Coordination investigation of rhenium with MAG3 using LC-MS and UV spectrometer and the simple radiolabelling process
Due to the low concentration of 188Re-radiopharmaceuticals, identity confirmation of the complex is generally performed only indirectly by assessment of their retention time on HPLC. Herein, LC-MS and UV spectrom...
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Article
Adsorption kinetic, isotherm and thermodynamic studies of Sr2+ onto hexagonal tungsten oxide
Hexagonal tungsten oxide (hex-WO3) with exchangeable sodium and ammonium cations located in hexagonal channel was synthesized by a facile hydrothermal treatment of sodium tungstate dihydrate in concentrated HCl s...
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Article
In vivo biological behavior of 99mTc(CO)3 labeled fullerol
The mass production and extensive applications of nanomaterials may have potential negative effects on health of human beings. Research on the in vivo behavior of fullerene, the most representative nanomateria...
