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    Book

    Lentiviral Vectors and Gene Therapy

    David Escors, Karine Breckpot… in SpringerBriefs in Biochemistry and Molecular Biology (2012)

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    Chapter

    Clinical Grade Lentiviral Vectors

    Thirty years of extensive research culminated in the year 2000 with the publication of the first clearly successful human gene therapy clinical trial. The trial corrected X-linked severe combined immunodeficie...

    Grazyna Kochan, David Escors, Holly Stephenson… in Lentiviral Vectors and Gene Therapy (2012)

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    Chapter

    Development of Retroviral and Lentiviral Vectors

    Gene vectors based on human immunodeficiency virus 1 (HIV-1) are becoming popularly used as gene carriers. HIV-1 lentivectors have recently been used in two gene therapy clinical trials for the correction of β-th...

    David Escors, Grazyna Kochan, Holly Stephenson… in Lentiviral Vectors and Gene Therapy (2012)

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    Chapter

    Human Gene Therapy with Retrovirus and Lentivirus Vectors

    The first human gene therapy clinical trial unsuccessfully took place in the 1970s. Despite extensive research and development in this subject, it was only approximately 10 years ago in 2000, that the results ...

    Grazyna Kochan, Holly Stephenson, Karine Breckpot… in Lentiviral Vectors and Gene Therapy (2012)

  5. Chapter

    Cell and Tissue Gene Targeting with Lentiviral Vectors

    One of the main advantages of using lentivectors is their capacity to transduce a wide range of cell types, independently from the cell cycle stage. However, transgene expression in certain cell types is somet...

    David Escors, Grazyna Kochan, Holly Stephenson… in Lentiviral Vectors and Gene Therapy (2012)

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