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Article
Open AccessAmino acid-based formula affects the gastrointestinal cytokine milieu of children with non-IgE mediated cow’s milk allergy
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Book
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Chapter
Clinical Grade Lentiviral Vectors
Thirty years of extensive research culminated in the year 2000 with the publication of the first clearly successful human gene therapy clinical trial. The trial corrected X-linked severe combined immunodeficie...
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Chapter
Development of Retroviral and Lentiviral Vectors
Gene vectors based on human immunodeficiency virus 1 (HIV-1) are becoming popularly used as gene carriers. HIV-1 lentivectors have recently been used in two gene therapy clinical trials for the correction of β-th...
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Chapter
Human Gene Therapy with Retrovirus and Lentivirus Vectors
The first human gene therapy clinical trial unsuccessfully took place in the 1970s. Despite extensive research and development in this subject, it was only approximately 10 years ago in 2000, that the results ...
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Chapter
Cell and Tissue Gene Targeting with Lentiviral Vectors
One of the main advantages of using lentivectors is their capacity to transduce a wide range of cell types, independently from the cell cycle stage. However, transgene expression in certain cell types is somet...