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  1. No Access

    Article

    Influence of Cytochrome P450 (CYP) 3A5 Polymorphisms on the Pharmacokinetics of Lansoprazole Enantiomers in CYP2C19 Extensive Metaboliser Renal Transplant Recipients

    Background and objective: Lansoprazole is extensively metabolised by cytochrome P450 (CYP) 2C19 and CYP3A4. The purpose of this study was to evaluate the effects of CYP3A5 polymorphism (A6986G) o...

    Dr Masatomo Miura, Kazuyuki Inoue, Shigeru Satoh… in Clinical Drug Investigation (2007)

  2. No Access

    Article

    Influence of UGT1A8 and UGT2B7 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients

    UGT1A8 and UGT2B7 are important uridine diphosphate-glucuronosyltransferase isoforms for the glucuronidation of mycophenolic acid (MPA). The aim of this investigation was to elucidate MPA pharmacokinetics in U...

    Hideaki Kagaya, Kazuyuki Inoue, Masatomo Miura… in European Journal of Clinical Pharmacology (2007)

  3. No Access

    Article

    Stereoselective metabolism of rabeprazole-thioether to rabeprazole by human liver microsomes

    Rabeprazole is metabolized mainly non-enzymatically to rabeprazole-thioether. This in vitro study was designed to clarify the stereoselective oxidation mechanism and to identify the enzyme(s) involved in the m...

    Masatomo Miura, Shigeru Satoh, Hitoshi Tada… in European Journal of Clinical Pharmacology (2006)

  4. No Access

    Article

    Neural Mechanism of Acupuncture-Induced Gastric Relaxations in Rats

    Acupuncture has been used to treat gastrointestinal symptoms in China for more than 3000 years. However, the mechanism of the beneficial effects of acupuncture remains unknown. Strain gauge transducers were im...

    Hitoshi Tada, Mikio Fujita, Mary Harris, Makoto Tatewaki… in Digestive Diseases and Sciences (2003)

  5. No Access

    Article

    Characterization of B16 melanoma-specific cytotoxic T lymphocytes

    A B16 melanoma-specific CD8+ T cell line (AB1) was established from the spleen cells of C57BL/6 mice cured of B16 melanoma with interleukin (IL)-12 treatment. The AB1 line exclusively used T cell receptor Vβ11. ...

    Mamoru Harada, Koji Tamada, Koichiro Abe, Tieli Li… in Cancer Immunology, Immunotherapy (1998)

  6. No Access

    Article

    Antitumor vaccination effect of dendritic cells can be augmented by locally utilizing Th1-type cytokines from OK432-reactive CD4+ T cells

     In order to enhance the antitumor vaccination effect of dendritic cells (DC) pulsed with class I tumor peptide, we tried to utilize the local cytokine help of CD4+ T cells reactive to a streptococcal preparation...

    Koji Tamada, M. Harada, Koichiro Abe, Tieli Li… in Cancer Immunology, Immunotherapy (1998)

  7. No Access

    Article

    Characteristics of MOCVD-Grown AlGaAs/GaAs SQW LASERS and GaAs MESFETs Fabrication on Si Substrate with SiO2-Back Coating

    We discuss room temperature CW operation of AlGaAs/GaAs SQW lasers and GaAs MESFETs with good pinch-off characteristic on SiO2-back coated Si. The all-MOCVD-grown,QW lpser on Si with thermal-cycle annealing, whic...

    Takashi Egawa, Hitoshi Tada, Yasufumi Kobayashi… in MRS Online Proceedings Library (1990)