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  1. Article

    Open Access

    Analysis of proteins released from osteoarthritic cartilage by compressive loading

    In osteoarthritis (OA), synovial pathology may be induced by proteins released from degenerated cartilage. This study was conducted to identify the proteins released from OA cartilage. OA cartilage was obtaine...

    Hirotaka Tsuno, Nobuho Tanaka, Masashi Naito, Satoru Ohashi in Scientific Reports (2023)

  2. Article

    Open Access

    The attenuation of insulin-like growth factor signaling may be responsible for relative reduction in matrix synthesis in degenerated areas of osteoarthritic cartilage

    In osteoarthritis (OA), cartilage matrix is lost gradually despite enhanced matrix synthesis by chondrocytes. This paradox may be explained, at least partly, by reduced chondrocyte anabolism in degenerated are...

    Nobuho Tanaka, Hirotaka Tsuno, Satoru Ohashi in BMC Musculoskeletal Disorders (2021)

  3. Article

    Open Access

    A proteomic analysis of serum-derived exosomes in rheumatoid arthritis

    To understand the roles of serum exosomes in rheumatoid arthritis (RA), we comprehensively investigated the protein profiles of serum exosomes in patients with RA.

    Hirotaka Tsuno, Mitsumi Arito, Naoya Suematsu, Toshiyuki Sato in BMC Rheumatology (2018)

  4. No Access

    Article

    Mycophenolate mofetil therapy for rapidly progressive interstitial lung disease in a patient with clinically amyopathic dermatomyositis

    Haruka Tsuchiya, Hirotaka Tsuno, Mariko Inoue, Yuko Takahashi in Modern Rheumatology (2013)