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Article
Open AccessInfiltrating CCR2+ monocytes and their progenies, fibrocytes, contribute to colon fibrosis by inhibiting collagen degradation through the production of TIMP-1
Intestinal fibrosis is a serious complication in inflammatory bowel disease (IBD). Despite the remarkable success of recent anti-inflammatory therapies for IBD, incidence of intestinal fibrosis and need for bo...
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Article
Overexpression of salivary-type amylase reduces the sensitivity to bortezomib in multiple myeloma cells
Amylase-producing myeloma exhibits refractoriness to chemotherapy and a dismal prognosis. In this study, we established a human myeloma cell line, 8226/AMY1, in which a lentivirally transfected AMY1 gene was stab...
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Article
Open AccessAdaptation of leukemia cells to hypoxic condition through switching the energy metabolism or avoiding the oxidative stress
Like normal hematopoietic stem cells, leukemia cells proliferate in bone marrow, where oxygen supply is limited. However, the growth and energy metabolism of leukemia cells under hypoxia have not been well und...
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Article
T-Cell Acute Lymphoblastic Leukemia as a Secondary Leukemia after a 3-Year Remission of Acute Myelocytic Leukemia
Therapy-related myelodysplastic syndrome and therapy-related acute myelocytic leukemia (AML) are now recognized as hematologic malignancies that occur a few years after chemotherapy for primary malignancy with...
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Article
Lineage Conversion From Acute Lymphoblastic Leukemia to Acute Myeloid Leukemia on Rearrangement of the IgH Gene in a Patient with Down Syndrome
A patient with Down syndrome (DS) at the time of diagnosis of acute lymphoblastic leukemia (ALL) had a relapse with acute myeloid leukemia (AML) after 4 years of complete remission. Although the diagnosis was ...
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Article
Two Independent Clones in Myelodysplastic Syndrome Following Treatment of Acute Myeloid Leukemia
We describe a 55-year-old Japanese woman with therapy-related myelodysplastic syndrome (t-MDS) with 2 independent clones, t(1;2)(p36;p21) and t(11;12)(p15;q13). She was diagnosed with acute myeloid leukemia (A...
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Article
Atrial reservoir and active transport function after cardioversion of chronic atrial fibrillation
Atrial reservoir function has not been studied after successful cardioversion of chronic atrial fibrillation. Using transthoracic and transesophageal Doppler echocardiography, we measured flow velocitytime int...
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Article
Liver sarcoidosis showing low-density intrahepatic septa on postcontrast computed tomography
The authors present a patient with massive liver sarcoidosis, showing only slight hepatomegaly on precontrast computed tomogram and multiple low-density intrahepatic septa on postocontrast computed tomogram. S...
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Article
Time-course of recovery of atrial contraction after cardioversion of chronic atrial fibrillation
We aimed to study the time-course of recovery of atrial contraction after cardioversion of chronic atrial fibrillation (duration of more than 3 months) to sinus rhythm. Using M-mode, two-dimensional and pulsed...
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Pulmonary Vein Flow Velocity-Time Profile for Semiquantitative Estimates of Left Atrial Storage Fraction
To evaluate the usefulness of a method of estimating the ratio of left atrial (LA) storage volume to left ventricular (LV) stroke volume (i.e., the LA storage fraction) by Doppler echocardiography, we compared...
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Article
Diastolic compliance of the left atrium in man: A determinant of preload of the left ventricle
During the ventricular slow-filling period, both the left atrium and left ventricle fill passively, and their respective internal pressures equalize, becoming evenly elevated. If the diastolic chamber complian...
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Article
Two major subgroups of human T-Cell leukemia virus-1 in Japan
T lymphocytes of patients with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM) were cultured. After cultivating for several months, HAM-derived cell lines were tested for the presence o...
