-
Article
Successful treatment of pediatric patients with high-grade gliomas featuring leptomeningeal metastases by targeting BRAF V600E mutations with dabrafenib plus trametinib: two illustrative cases
A combination of BRAF and MEK inhibitors is reported to be effective for gliomas with the BRAF V600E mutation; however, its efficacy in gliomas with leptomeningeal metastases (LMM) is still unknown. In this re...
-
Article
Open AccessA method for delivering the required neutron fluence in an accelerator-based boron neutron capture therapy system employing a lithium target
Accelerator-based boron neutron capture therapy (BNCT) systems employing a solid-state lithium target indicated the reduction of neutron flux over the lifetime of a target, and its reduction could represent th...
-
Article
Experimental designs for radiobiological characterization of an accelerator-based BNCT system in preclinical studies
Several types of accelerator-based boron neutron capture therapy (AB-BNCT) systems have been developed; however, the features of neutron beams differ among facilities depending on the target type and accelerat...
-
Article
Magnetic resonance-based imaging biopsy with signatures including topological Betti number features for prediction of primary brain metastatic sites
This study incorporated topology Betti number (BN) features into the prediction of primary sites of brain metastases and the construction of magnetic resonance-based imaging biopsy (MRB) models. The significan...
-
Article
Open AccessPrognostic factors associated with the transition in treatment methods for brain metastases from colorectal cancer
Treatment of brain metastases (BMs) from colorectal cancer (CRC) has transitioned with the expansion of indications for stereotactic radiotherapy. Our study aimed to assess changes in prognosis and prognostic ...
-
Chapter
ViewRay MR-Linac
The MRIdian®-Linac (Viewray, Oakwood Village, OH, USA) is a cancer treatment system that combines a magnetic resonance (MR) scanner with a radiotherapy system mounted on a ring-type rotating gantry (Fig. 21.1) [1...
-
Article
Open AccessAnalyzing spatial distribution between 18F-fluorodeoxyglucose and 18F-boronophenylalanine positron emission tomography to investigate selection indicators for boron neutron capture therapy
18F-FDG PET is often utilized to determine BNCT selection due to the limited availability of 18F-BPA PET, which is performed by synthesizing 18F into the boron drug used for BNCT, although the uptake mechanisms b...
-
Article
Open AccessAssessment of therapeutic outcome and role of reirradiation in patients with radiation-induced glioma
We sought to clarify the optimal follow-up, therapeutic strategy, especially the role of reirradiation, and the diagnostic impact of isocitrate dehydrogenase (IDH) 1 and 2 mutation status in patients with radiati...
-
Article
Open AccessMGMT gene promoter methylation by pyrosequencing method correlates volumetric response and neurological status in IDH wild-type glioblastomas
Although the usefulness of O6-methylguanine DNA methyltransferase (MGMT) promoter methylation analysis for predicting response to chemoradiotherapy and the prognosis of patients with glioblastoma has been widely ...
-
Article
Open AccessPrognostic factor analysis of definitive radiotherapy using intensity-modulated radiation therapy and volumetric modulated arc therapy with boluses for scalp angiosarcomas
Cutaneous angiosarcomas is a rare cancer with poor prognoses. The common radiotherapy techniques that have been reported so far are two pairs of lateral X-ray and electron fields. However, it is quite difficul...
-
Article
Open AccessMonte Carlo simulation of tilted contact plaque brachytherapy placement for juxtapapillary retinoblastoma
The 106-Ruthenium contact plaque applicator is utilized for the treatment of intraocular tumor within a thickness of less than 6 mm. If anything obstructs the placement of the plaque applicator, the treatment ...
-
Article
Open AccessEvaluation of auto-segmentation accuracy of cloud-based artificial intelligence and atlas-based models
Contour delineation, a crucial process in radiation oncology, is time-consuming and inaccurate due to inter-observer variation has been a critical issue in this process. An atlas-based automatic segmentation w...
-
Article
Open AccessNeutron flux evaluation model provided in the accelerator-based boron neutron capture therapy system employing a solid-state lithium target
An accelerator-based boron neutron capture therapy (BNCT) system employing a solid-state Li target can achieve sufficient neutron flux for treatment although the neutron flux is reduced over the lifetime of it...
-
Article
Open AccessThe use of hyperbaric oxygen to treat actinic rectal fistula after SpaceOAR use and radiotherapy for prostate cancer: a case report
In definitive radiation therapy for prostate cancer, the SpaceOAR® System, a hydrogel spacer, is widely used to decrease the irradiated dose and toxicity of rectum. On the other hand, periprostatic abscesses f...
-
Article
Open AccessNon-invasive quantitative measures of qualitative grading effectiveness as the indices of acute radiation dermatitis in breast cancer patients
Recent improvement of machinery evaluation for the skin changes in various therapies enabled us to evaluate fine changes quantitatively. In this study, we performed evaluation of the changes in radiation derma...
-
Article
Open AccessSurvival benefits of hypofractionated radiotherapy combined with temozolomide or temozolomide plus bevacizumab in elderly patients with glioblastoma aged ≥ 75 years
The purpose of this study was to evaluate the outcomes of elderly patients (aged ≥75 years) with newly diagnosed glioblastoma (GBM), who were treated with hypofractionated radiotherapy comprising 45 Gy in 15 f...
-
Article
Open AccessPrognostic factors of brain metastases from colorectal cancer
For brain metastases from non-specific primary tumors, the most frequently used and validated clinical prognostic assessment tool is Karnofsky performance status (KPS). Given the lack of prognostic factors of ...
-
Article
Open AccessDummy-run for standardizing plan quality of intensity-modulated radiotherapy for postoperative uterine cervical cancer: Japan Clinical Oncology Group study (JCOG1402)
The purpose of this study was to assess compliance with treatment planning in a dummy-run for a multicenter clinical trial involving patients with high-risk postoperative uterine cervical cancer using intensit...
-
Article
Open AccessA hybrid technique of intracavitary and interstitial brachytherapy for locally advanced cervical cancer: initial outcomes of a single-institute experience
Locally advanced uterine cervical cancer (LAUCC) with lateral tumor extension may not always be covered adequately by conventional intracavitary brachytherapy (ICBT). Hybrid intracavitary and interstitial brac...
-
Article
Present clinical practices of stereotactic irradiation for metastatic brain tumors in Japan: results of questionnaire survey of the Japanese Radiation Oncology Study Group (JROSG) working subgroup for neurological tumors
To determine the current practice of stereotactic irradiation (STI) for brain metastases in Japan by a questionnaire survey.
