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Article
Open AccessEribulin induces micronuclei and enhances the nuclear localization of cGAS in triple-negative breast cancer cells
Eribulin (ERI), clinically utilized for locally advanced or metastatic breast tumors, has shown potential links to the immune system. Notably, the cGAS-STING pathway, a key component of innate immunity, has ga...
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Article
Ex vivo dual gene therapy using human adipocytes secreting anti-HER2 antibody on HER2-positive xenograft tumor models
Although targeted treatments against human epidermal growth factor receptor 2 (HER2) have improved survival in patients with metastatic HER2-positive breast cancer, long and repeated treatment is time-consumin...
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Article
Open AccessA review of MRI (CT)/US fusion imaging in treatment of breast cancer
The ultrasound fusion imaging system is a diagnostic device developed in Japan that utilizes ultrasound and magnetic positioning/navigation. A position sensor with a probe reads spatial location information fr...
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Article
Open AccessThe impact of PIK3CA mutations and PTEN expression on the effect of neoadjuvant therapy for postmenopausal luminal breast cancer patients
There is pressing needs to find the biomarker in the selection of neoadjuvant therapy in postmenopausal luminal breast cancer patients. We examined the hypothesis that PIK3CA mutations and low phosphatase and ten...
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Article
Open AccessEvaluation of pretreatment ADC values as predictors of treatment response to neoadjuvant chemotherapy in patients with breast cancer - a multicenter study
Magnetic resonance imaging (MRI) can be used to diagnose breast cancer. Diffusion weighted imaging (DWI) and the apparent diffusion coefficient (ADC) can reflect tumor microstructure in a non-invasive manner. ...
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Article
Braille learning materials for Braille reading novices: experimental determination of dot code printing area for a pen-type interface read aloud function
This study clarifies a previously established method in which Braille reading novices obtained Braille information aurally. Therein, users touched the vicinity of the Braille with a pen-type interface characte...
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Article
Anti-HER2 antibody therapy using gene-transduced adipocytes for HER2-positive breast cancer
Although recent advances in molecular target therapy have improved the survival of breast cancer patients, high cost and frequent hospital visits result in both societal and individual burden. To reduce these ...
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Article
Histological features of skin and subcutaneous tissue in patients with breast cancer who have received neoadjuvant chemotherapy and their relationship to post-treatment edema
Lymphedema is a major complication of treatment for breast cancer. Although chemotherapy can cause lymphedema, there have been few reports about histological changes in skin and subcutaneous tissue after chemo...
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Chapter and Conference Paper
Recent Advancements in Continuous Wheel Slip Control
The paper presents an overview of continuous wheel slip control (WSC) methods as the part of anti-lock braking system (ABS) for the several vehicles configurations with friction brakes and electric motors. Per...
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Chapter
Range Extension Autonomous Driving for Electric Vehicles Based on Optimization of Velocity Profile Considering Traffic Signal Information
Electric vehicles (EVs) have been recognized as a practical solution to several environmental and energy conservation problems. The mileage per charge of EVs, however, is lower than the mileage of internal com...
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Article
Quality and quantity of visceral fat tissue are associated with insulin resistance and survival outcomes after chemotherapy in patients with breast cancer
Recent studies suggest that the quality and quantity of visceral adipose tissue (VAT) play significant roles in adipocyte function, and are related to insulin resistance. We tested the hypothesis that high amo...
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Article
Coexistence of regulatory B cells and regulatory T cells in tumor-infiltrating lymphocyte aggregates is a prognostic factor in patients with breast cancer
Tumors can acquire tolerance to tumor immunity and develop enhanced proliferation. Regulatory B cells (Bregs), whose role in immune tolerance is similar to that of regulatory T cells (Tregs), appear to be invo...
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Chapter and Conference Paper
The Development of Sensor-Based Gait Training System for Locomotive Syndrome: The Effect of Real-Time Gait Feature Feedback on Gait Pattern During Treadmill Walking
The concept of locomotive syndrome was proposed by the Japanese Orthopedic Association; it typifies the condition of reduced mobility resulting from a locomotive organ disorder related to aging. Although sever...
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Article
Polyurethane Foam Wound Dressing Technique for Areola Skin Graft Stabilization and Nipple Protection After Nipple–Areola Reconstruction
We describe a new wound management technique using a soft dressing material to stabilize the areola skin graft and protect the nipple after nipple–areola reconstruction at the final stage of breast reconstruct...
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Article
Open AccessInfluence of vacuum chamber impurities on the lifetime of organic light-emitting diodes
We evaluated the influence of impurities in the vacuum chamber used for the fabrication of organic light-emitting diodes on the lifetime of the fabricated devices and found a correlation between lifetime and t...
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Article
Cancer-mediated adipose reversion promotes cancer cell migration via IL-6 and MCP-1
The objective of this study is to investigate interactions between adipocytes and breast cancer cells, and identify the responsible factors for the observed effects. In 27 breast cancer patients undergoing mas...
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Article
Diffusion-weighted imaging reflects pathological therapeutic response and relapse in breast cancer
Conventional imaging does not always accurately depict the pathological response to neoadjuvant chemotherapy (NAC). Diffusion-weighted imaging (DWI) may provide additional insight into the chemotherapeutic eff...
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Article
Measurement of local electric field in microdevices for low-voltage electroporation of adherent cells
In this study, we present the measurement of the local electric field in a microdevice designed for electroporation of adherent cells. The microdevice mainly consists of a coverslip that has a transparent cond...
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Article
A step forward in development of fish protein hydrolysate-based diets for larvae of Japanese eel Anguilla japonica
Eggs of spiny dogfish Squalus acanthias are an indispensable and effective component of the compound diets currently used for larvae of the Japanese eel Anguilla japonica. However, this fish speci...
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Article
Open AccessPhosphorylation of BLUS1 kinase by phototropins is a primary step in stomatal opening
Opening of stomata in the plant facilitates photosynthetic CO2 fixation and transpiration. Blue-light perception by phototropins (phot1, phot2) activates the plasma membrane H+-ATPase, causing stomata to open. He...
