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  1. No Access

    Article

    Panitumumab in combination with irinotecan plus S-1 (IRIS) as second-line therapy for metastatic colorectal cancer

    Irinotecan plus S-1 (IRIS) is the only oral fluoropyrimidine-based regimen reported to be non-inferior to FOLFIRI and widely used in clinical practice for metastatic colorectal cancer (mCRC) patients. However,...

    Toshi Takaoka, Tetsuo Kimura, Rai Shimoyama… in Cancer Chemotherapy and Pharmacology (2016)

  2. Article

    Interferon-beta, but not tumor necrosis factor-alpha, production in response to poly I:C is maintained despite exhaustive exercise in mice

    It remains unclear whether immune response to viral infection is inhibited by severe exercise. We determined whether exhaustive exercise inhibits interferon (IFN)-β and tumor necrosis factor (TNF)-α production...

    Masataka Uchida, Eri Oyanagi, Michael J. Kremenik… in The Journal of Physiological Sciences (2012)

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  3. Article

    Exhaustive exercise reduces TNF-α and IFN-α production in response to R-848 via toll-like receptor 7 in mice

    Stressful exercise results in temporary immune depression. However, the impact of exercise on the immune responses via toll-like receptor (TLR) 7, which recognizes the common viral genomic feature, single-stra...

    Hiromi Yano, Masataka Uchida, Ryosuke Nakai… in European Journal of Applied Physiology (2010)

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  4. No Access

    Article

    l-Carnitine is essential to β-oxidation of quarried fatty acid from mitochondrial membrane by PLA2

    Mitochondrial β-oxidation is an important system involved in the energy production of various cells. In this system, the function of l-carnitine is essential for the uptake of fatty acids to mitochondria. However...

    Hiromi Yano, Eri Oyanagi, Yasuko Kato… in Molecular and Cellular Biochemistry (2010)

  5. No Access

    Article

    Stretch reflex modulation during imposed static and dynamic hip movements in standing humans

    The purpose of this study was to investigate the effects of hip proprioceptors on soleus stretch reflex excitability in standing humans. A custom-made device to stretch the ankle extensors was mounted on the l...

    Noritaka Kawashima, Hiromi Yano, Yuji Ohta… in Experimental Brain Research (2006)

  6. No Access

    Chapter and Conference Paper

    Attribute Intensity Calculating Method from Evaluative Sentences by Fuzzy Inference

    We propose a method to calculate the attribute’s intensity of an object from multiple opinions. The intensity is calculated by min-max inference and the membership value of each degree group is obtained from t...

    Kazuya Mera, Hiromi Yano, Takumi Ichimura in Knowledge-Based Intelligent Information an… (2005)

  7. No Access

    Article

    Acute exercise induces gastrointestinal leakage of allergen in lysozyme-sensitized mice

    Food-dependent exercise-induced anaphylaxis (FDEIAn) is a leading cause of physical allergies. However, the mechanisms involved in the development of FDEIAn are not yet clearly understood. In this study, to i...

    Hiromi Yano, Yasuko Kato, Tsukasa Matsuda in European Journal of Applied Physiology (2002)