13 Result(s)
within
Hiroaki Tanaka
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessAssociation between parental decisions regarding abortion and severity of fetal heart disease
The prenatal diagnosis of fetal heart disease potentially influences parental decision-making regarding pregnancy termination. Existing literature indicates that the severity, whether in complexity or lethalit...
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Open AccessAccurate evaluation of the progress of delivery with transperineal ultrasound may improve vaginal delivery: a single-center retrospective study
Although digital examination of the cervix is the standard method used worldwide for evaluating the progress of delivery, it is subjective. Transperineal ultrasound (TPU) is combined with digital evaluation fo...
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Article
Open AccessExcessive excitability of inhibitory cortical circuit and disturbance of ballistic targeting movement in degenerative cerebellar ataxia
This study aimed to investigate abnormalities in inhibitory cortical excitability and motor control during ballistic-targeting movements in individuals with degenerative cerebellar ataxia (DCA). Sixteen partic...
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Article
Open AccessHigh maternal mortality rate associated with advanced maternal age in Japan
This study aimed to clarify the relationship between maternal mortality and advanced maternal age in Japan and to provide useful information for future perinatal management. Maternal death rates by age group w...
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Article
Open AccessPrognostic impact of postoperative systemic inflammatory response in patients with stage II/III gastric cancer
This study examined whether the systemic inflammatory response present in the early phase of the postoperative state correlates with long-term outcomes and to identify markers in patients with stage II/III gas...
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Article
Open AccessMaternal tadalafil therapy for fetal growth restriction prevents non-alcoholic fatty liver disease and adipocyte hypertrophy in the offspring
We aimed to investigate the effects of maternal tadalafil therapy on fetal programming of metabolic function in a mouse model of fetal growth restriction (FGR). Pregnant C57BL6 mice were divided into the contr...
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Open AccessHuman health risk assessment of elevated and variable iron and manganese intake with arsenic-safe groundwater in Jashore, Bangladesh
Groundwater through hand-operated tubewell (a type of water well) tap** is the main source of drinking water in Bangladesh. This study investigated iron and manganese concentration in groundwater across Jash...
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Open AccessFragment-based discovery of the first nonpeptidyl inhibitor of an S46 family peptidase
Antimicrobial resistance is a global public threat and raises the need for development of new antibiotics with a novel mode of action. The dipeptidyl peptidase 11 from Porphyromonas gingivalis (PgDPP11) belongs t...
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Article
Open AccessDecline in maternal death due to obstetric haemorrhage between 2010 and 2017 in Japan
This descriptive study was based on the maternal death registration system established by the Japan Association of Obstetricians and Gynecologists and the Maternal Death Exploratory Committee (JMDEC). 361 wome...
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Article
Open AccessTadalafil treatment in mice for preeclampsia with fetal growth restriction has neuro-benefic effects in offspring through modulating prenatal hypoxic conditions
We have demonstrated that tadalafil facilitates fetal growth in mice with L-NG-nitroarginine methyl ester (L-NAME)-induced preeclampsia (PE) with fetal growth restriction (FGR). Tadalafil is a selective phosph...
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Article
Open AccessNext-generation amplicon sequencing identifies genetically diverse human astroviruses, including recombinant strains, in environmental waters
Human astroviruses are associated with gastroenteritis and known to contaminate water environments. Three different genetic clades of astroviruses are known to infect humans and each clade consists of diverse ...
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Article
Open AccessStructural and mutational analyses of dipeptidyl peptidase 11 from Porphyromonas gingivalis reveal the molecular basis for strict substrate specificity
The dipeptidyl peptidase 11 from Porphyromonas gingivalis (PgDPP11) belongs to the S46 family of serine peptidases and preferentially cleaves substrates with Asp/Glu at the P1 position. The molecular mechanism un...
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Article
Open AccessS46 Peptidases are the First Exopeptidases to be Members of Clan PA
The dipeptidyl aminopeptidase BII (DAP BII) belongs to a serine peptidase family, S46. The amino acid sequence of the catalytic unit of DAP BII exhibits significant similarity to those of clan PA endopeptidase...
