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  1. No Access

    Article

    Antibody response after third dose of COVID-19 mRNA vaccination in allogeneic hematopoietic stem cell transplant recipients is comparable to that in healthy counterparts

    To determine the efficacy of SARS-CoV-2 mRNA vaccination for allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients, we measured antibody titer serially in 92 allo-HSCT patients. Among the e...

    Erina Takagi, Seitaro Terakura, Hidetsugu Fujigaki… in International Journal of Hematology (2023)

  2. Article

    Open Access

    Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues

    The enzyme kynurenine aminotransferase (KAT) catalyses the conversion of kynurenine (KYN) to kynurenic acid (KYNA). Although the isozymes KAT1–4 have been identified, KYNA is mainly produced by KAT2 in brain t...

    Yukihiro Yoshida, Hidetsugu Fujigaki, Koichi Kato, Kyoka Yamazaki… in Scientific Reports (2019)

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  3. Article

    Open Access

    Lipopolysaccharide shock reveals the immune function of indoleamine 2,3-dioxygenase 2 through the regulation of IL-6/stat3 signalling

    Indoleamine 2,3-dioxygenase 2 (Ido2) is a recently identified catalytic enzyme in the tryptophan-kynurenine pathway that is expressed primarily in monocytes and dendritic cells. To elucidate the biological rol...

    Yasuko Yamamoto, Wakana Yamasuge, Shinjiro Imai, Kazuo Kunisawa… in Scientific Reports (2018)

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  4. Article

    Open Access

    Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1

    Depression is known to occur frequently in chronic hepatitis C viral (HCV) patients receiving interferon (IFN)-α therapy. In this study, we investigated whether indoleamine 2,3-dioxygenase1 (IDO1)-mediated try...

    Yuki Murakami, Takaaki Ishibashi, Eiichi Tomita, Yukio Imamura… in Scientific Reports (2016)

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  5. No Access

    Article

    Posttranslational modification of indoleamine 2,3-dioxygenase

    Protein posttranslational modifications (PTMs) perform essential roles in the biological regulation of a cell. PTMs are extremely important because they can change a protein’s physical or chemical properties, ...

    Hidetsugu Fujigaki, Mitsuru Seishima… in Analytical and Bioanalytical Chemistry (2012)

  6. No Access

    Article

    Programmable multivalent display of receptor ligands using peptide nucleic acid nanoscaffolds

    Multivalent effects dictate the binding affinity of multiple ligands on one molecular entity to receptors. Integrins are receptors that mediate cell attachment through multivalent binding to peptide sequences ...

    Ethan A. Englund, Deyun Wang, Hidetsugu Fujigaki, Hiroyasu Sakai… in Nature Communications (2012)