21 Result(s)

Article

Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation

Observational studies suggest that abnormal glucose metabolism and insulin resistance contribute to colorectal cancer; however, the causal association remains unknown, particularly in Asian populations. A two-...

Akiko Hanyuda, Atsushi Goto, Ryoko Katagiri, Yuriko N. Koyanagi… in Scientific Reports (2023)

Article

Author Correction: Response to antiviral therapy for chronic hepatitis C and risk of hepatocellular carcinoma occurrence in Japan: a systematic review and meta-analysis of observational studies

Yoko Yamagiwa, Keitaro Tanaka, Keitaro Matsuo, Keiko Wada… in Scientific Reports (2023)

Article

Response to antiviral therapy for chronic hepatitis C and risk of hepatocellular carcinoma occurrence in Japan: a systematic review and meta-analysis of observational studies

In Japan, hepatocellular carcinoma (HCC) is a leading cause of cancer mortality and hepatitis C virus infection is a major cause of HCC. We conducted a systematic review and meta-analysis of published studies ...

Yoko Yamagiwa, Keitaro Tanaka, Keitaro Matsuo, Keiko Wada… in Scientific Reports (2023)

Article

Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach

The association between vitamin D and total and colorectal cancer risk was inconsistent in observational studies. We conducted Mendelian randomization approach in which the effect of confounding might be reduc...

Ryoko Katagiri, Atsushi Goto, Shiori Nakano, Masahiro Nakatochi… in Scientific Reports (2023)

Article

Association of perceived stress and co** strategies with the renal function in middle-aged and older Japanese men and women

Elucidating the risk factors for chronic kidney disease is important for preventing end-stage renal disease and reducing mortality. However, little is known about the roles of psychosocial stress and stress co...

Kayoko Koga, Megumi Hara, Chisato Shimanoe, Yuichiro Nishida… in Scientific Reports (2022)

Article

Association between plasma levels of homocysteine, folate, and vitamin B₁₂, and dietary folate intake and hypertension in a cross-sectional study

There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B₁₂ as related to Hcy level. We simultaneously examined the ...

Takashi Tamura, Nagato Kuriyama, Teruhide Koyama, Etsuko Ozaki… in Scientific Reports (2020)

Article

European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women u...

Weang-Kee Ho, Min-Min Tan, Nasim Mavaddat, Mei-Chee Tai… in Nature Communications (2020)

Article

Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer

Pancreatic cancer is the fourth leading cause of cancer-related deaths in Japan. To identify risk loci, we perform a meta-analysis of three genome-wide association studies comprising 2,039 pancreatic cancer pa...

Yingsong Lin, Masahiro Nakatochi, Yasuyuki Hosono, Hidemi Ito… in Nature Communications (2020)

Article

Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk

In breast cancer, high levels of homeobox protein Hox-B13 (HOXB13) have been associated with disease progression of ER-positive breast cancer patients and resistance to tamoxifen treatment. Since HOXB13 p.G84E is...

**g**g Liu, Wendy J. C. Prager - van der Smissen… in Scientific Reports (2020)

Article

Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-an...

**ang Shu, Jirong Long, Qiuyin Cai, Sun-Seog Kweon, Ji-Yeob Choi… in Nature Communications (2020)

Article

Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population

Genome-wide association studies (GWAS) have successfully identified about 70 genomic loci associated with breast cancer. Owing to the complexity of linkage disequilibrium and environmental exposures in differe...

Siew-Kee Low, Yoon Ming Chin, Hidemi Ito, Keitaro Matsuo… in Scientific Reports (2019)

Article

Two truncating variants in FANCC and breast cancer risk

Fanconi anemia (FA) is a genetically heterogeneous disorder with 22 disease-causing genes reported to date. In some FA genes, monoallelic mutations have been found to be associated with breast cancer risk, whi...

Thilo Dörk, Paolo Peterlongo, Arto Mannermaa, Manjeet K. Bolla… in Scientific Reports (2019)

Article

Correction: Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

Nature Communications 5: Article number: 4999 (2014); Published: 23 September 2014; Updated: 10 April 2018 The original version of this Article had an incorrect volume number of 4; it should have been 5. This ...

Maya Ghoussaini, Stacey L. Edwards, Kyriaki Michailidou… in Nature Communications (2018)

Article

A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption: The J-MICC Study

Coffee is one of the most widely consumed beverages worldwide, and its role in human health has received much attention. Although genome-wide association studies (GWASs) have investigated genetic variants asso...

Hiroko Nakagawa-Senda, Tsuyoshi Hachiya, Atsushi Shimizu… in Scientific Reports (2018)

Article

Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population

The Tsuruoka Metabolomics Cohort Study included subjects aged 35–74 years from participants in annual health check-up programs in Tsuruoka, Japan. The gender-specific associations of early age-related macular ...

Mariko Sasaki, Sei Harada, Yumiko Kawasaki, Miki Watanabe, Hidemi Ito… in Scientific Reports (2018)

Article

rs2735383, located at a microRNA binding site in the 3’UTR of NBS1, is not associated with breast cancer risk

NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3′-untranslated region (UTR) of NBS1, was shown to be a...

**g**g Liu, Ivona Lončar, J. Margriet Collée, Manjeet K. Bolla… in Scientific Reports (2016)

Article

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls an...

Kate Lawrenson, Siddhartha Kar, Karen McCue, Karoline Kuchenbaeker… in Nature Communications (2016)

Article

Fine scale map** of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)

Genome-wide association studies have found SNPs at 17q22 to be associated with breast cancer risk. To identify potential causal variants related to breast cancer risk, we performed a high resolution fine-mappi...

Hatef Darabi, Jonathan Beesley, Arnaud Droit, Siddhartha Kar… in Scientific Reports (2016)