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Article
Risk factors of secondary cancer in laryngeal, oropharyngeal, or hypopharyngeal cancer after definitive therapy
Our previous research showed that a high rate of secondary carcinogenesis is observed during follow-up after transoral surgery in patients with early-stage laryngeal, oropharyngeal, and hypopharyngeal cancers....
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Chapter and Conference Paper
Restoration of Architectural Stone Heritage Damaged by 2011 Great East Japan Earthquake
The Great East Japan Earthquake of 2011 caused serious damage to a number of architectural heritages. Fukushima Photo Museum (Former Laboratory of Electrics Ministry of Communications), constructed in 1922 and...
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Article
Open AccessCombined oral intake of short and long fructans alters the gut microbiota in food allergy model mice and contributes to food allergy prevention
It has become clear that the intestinal microbiota plays a role in food allergies. The objective of this study was to assess the food allergy-preventive effects of combined intake of a short fructan (1-kestose...
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Article
Open AccessEstablishment of experimental salivary gland cancer models using organoid culture and patient-derived xenografting
Depending on its histological subtype, salivary gland carcinoma (SGC) may have a poor prognosis. Due to the scarcity of preclinical experimental models, its molecular biology has so far remained largely unknow...
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Article
Redox-induced dual optical switching of CaTiO3:Pr3+ phosphor nanoparticles synthesized by sol–gel method
Red-emitting CaTiO3:Pr3+ phosphor nanoparticles were synthesized by a sol–gel method with a final heat treatment at a low temperature of 650 °C. For comparison, the CaTiO3:Pr3+ phosphor was also synthesized by a ...
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Article
Open AccessIdentification of novel prognostic and predictive biomarkers in salivary duct carcinoma via comprehensive molecular profiling
Molecular targets and predictive biomarkers for prognosis in salivary duct carcinoma (SDC) have not been fully identified. We conducted comprehensive molecular profiling to discover novel biomarkers for SDC. A...
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Article
Open AccessIncidence of and risk factors for severe neutropenia during treatment with the modified FOLFIRINOX therapy in patients with advanced pancreatic cancer
Although FOLFIRINOX (l-Leucovorin/5-FU/Irinotecan/Oxaliplatin) is established as one of the standard therapies for patients with metastatic pancreatic cancer, the modified FOLFIRINOX (mFOLFIRINOX) is often used i...
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Article
Open AccessEffects of endoscopic injection sclerotherapy for esophagogastric varices on portal hemodynamics and liver function
To identify patients suitable for endoscopic injection sclerotherapy (EIS) by evaluating their portal hemodynamics and liver function.
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Article
Visceral disseminated varicella-zoster virus infection in an immunocompetent host
Varicella-zoster virus (VZV) can cause visceral disseminated VZV infection in immunocompromised patients. We experienced visceral disseminated VZV infection in an immunocompetent host. A 78-year-old woman visi...
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Article
A community approach to the cancer-variant-interpretation bottleneck
As guidelines, therapies and literature on cancer variants expand, the lack of consensus variant interpretations impedes clinical applications. CIViC is a public-domain, crowd-sourced and adaptable knowledgeba...
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Article
A risk factor for newly diagnosed secondary cancer in patients with early-stage laryngeal, oropharyngeal, or hypopharyngeal cancer: sub-analysis of a prospective observation study
We previously identified hypopharyngeal cancer as an independent risk factor for the incidence of newly diagnosed secondary cancers after the treatment of early-stage laryngeal, oropharyngeal, and hypopharynge...
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Article
Validation of the risk factors for primary control of early T-stage laryngeal, oropharyngeal, and hypopharyngeal squamous cell carcinoma by transoral surgery: a prospective observational study
We had previously identified the following risk factors for insufficient control of early T-stage head and neck cancer by transoral surgery (TOS): (1) tumor thickness > 7 mm on enhanced computed tomography (CT...
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Article
Open AccessFOLFIRINOX in advanced pancreatic cancer patients with the double-variant type of UGT1A1 *28 and *6 polymorphism: a multicenter, retrospective study
UGT1A1 *28 and *6 polymorphism is associated with reduced enzyme activity and severe toxicities of irinotecan, especially in patients with homozygous or heterozygous for UGT1A1*28 or *6 polymorphism for both U...
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Article
Open AccessThe Seasonality of Peripheral Venous Catheter-Related Bloodstream Infections
Although the seasonality of infectious diseases has been widely reported, the seasonality of peripheral venous catheter-related bloodstream infection (PV-CRBSI) has not been investigated. This study investigat...
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Article
Open AccessClinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (edition 2.1)
To promote precision oncology in clinical practice, the Japanese Society of Medical Oncology, the Japanese Society of Clinical Oncology, and the Japanese Cancer Association, jointly published “Clinical practic...
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Article
The incidence of newly diagnosed secondary cancer; sub-analysis the prospective study of the second-look procedure for transoral surgery in patients with T1 and T2 head and neck cancer
Our prospective study of patients with early T-stage head and neck cancer indicated a high incidence of newly diagnosed secondary malignancies during the follow-up period. We aimed to determine the incidence r...
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Article
Open AccessMulticentre, retrospective study of the efficacy and safety of nivolumab for recurrent and metastatic salivary gland carcinoma
Although immune-checkpoint inhibitors (ICIs) are effective against various cancers, little is known regarding their role in salivary gland carcinoma (SGC) treatment. Therefore, we evaluated the efficacy and sa...
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Article
Phase II clinical trial of gemcitabine plus oxaliplatin in patients with metastatic pancreatic adenocarcinoma with a family history of pancreatic/breast/ovarian/prostate cancer or personal history of breast/ovarian/prostate cancer (FABRIC study)
A family/personal history of breast, ovarian, or pancreatic cancer is a useful predictive marker for response to platinum-based chemotherapy in treating patients with pancreatic cancer. These cancers, and pros...
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Article
Chemotherapy-induced neutropenia as a prognostic factor in patients with pancreatic cancer treated with gemcitabine plus nab-paclitaxel: a retrospective cohort study
Chemotherapy-induced neutropenia (CIN) is a common adverse event of chemotherapy. Several reports have suggested that CIN could be an important prognostic factor in chemotherapy of various cancers. However, wh...
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Article
Open AccessThe clinicopathological significance of the adipophilin and fatty acid synthase expression in salivary duct carcinoma
Salivary duct carcinoma (SDC) is an aggressive, uncommon tumor histologically comparable to high-grade mammary ductal carcinoma. SDCs are usually androgen receptor (AR)–positive and often HER2-positive. Recent...
