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Open AccessAuthor Correction: DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death
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Open AccessDNA damage in circulating leukocytes measured with the comet assay may predict the risk of death
The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, m...
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Article
Open AccessMixed logistic regression in genome-wide association studies
Mixed linear models (MLM) have been widely used to account for population structure in case-control genome-wide association studies, the status being analyzed as a quantitative phenotype. Chen et al. proved in...
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Article
First genome-wide association study of non-severe malaria in two birth cohorts in Benin
Recent research efforts to identify genes involved in malaria susceptibility using genome-wide approaches have focused on severe malaria. Here, we present the first GWAS on non-severe malaria designed to ident...
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Article
Open AccessDetecting the dominance component of heritability in isolated and outbred human populations
Inconsistencies between published estimates of dominance heritability between studies of human genetic isolates and human outbred populations incite investigation into whether such differences result from part...
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Article
Open AccessAccuracy of heritability estimations in presence of hidden population stratification
The heritability of a trait is the proportion of its variance explained by genetic factors; it has historically been estimated using familial data. However, new methods have appeared for estimating heritabilit...
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Article
Open AccessA novel tree-based procedure for deciphering the genomic spectrum of clinical disease entities
Dissecting the genomic spectrum of clinical disease entities is a challenging task. Recursive partitioning (or classification trees) methods provide powerful tools for exploring complex interplay among genomic...
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Article
Space alternating penalized Kullback proximal point algorithms for maximizing likelihood with nondifferentiable penalty
The EM algorithm is a widely used methodology for penalized likelihood estimation. Provable monotonicity and convergence are the hallmarks of the EM algorithm and these properties are well established for smoo...
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Modeling the Effect of Susceptibility Factors (HLA and PTPN22) in Rheumatoid Arthritis
Numerous genome-wide analyses on common multifactorial diseases have been recently published in providing, for each associated Single Nucleotide Polymorphism (SNP), an Odds Ratio (OR), either for one of the su...
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Open AccessAn ordered subset approach to including covariates in the transmission disequilibrium test
Clinical heterogeneity of a disease may reflect an underlying genetic heterogeneity, which may hinder the detection of trait loci. Consequently, many statistical methods have been developed that allow for the ...
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Open AccessModeling the effect of PTPN22in rheumatoid arthritis
In order to model the effect of PTPN22 on rheumatoid arthritis (RA), we determined the combination of single-nucleotide-polymorphisms (SNPs) showing the strongest association with RA. Three SNPs (rs2476601-rs1273...
