Brain Imaging
The Chemistry of Mental Activity
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Henry N. Wagner Jr.
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Book
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Chapter
Measurements of Biochemical Reactions In Vivo
Immense progress has been made over the last century in medical diagnosis, especially in the techniques of radiological imaging. The evolution began in the mid-18908 by the epochal discoveries of Röntgen and B...
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Article
Assessing neuroreceptor occupancy by continuous infusion of carbon-11 labeled radioligands
In carbon-11 labeled radiotracer studies of neuroreceptors in the brain, a state of practical equilibrium, monitored with a simple dual-probe detector system, was achieved by injection of a bolus of tracer fol...
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Chapter
Cerebral Metabolic Rates of 2-[18F]Fluoro-2-Deoxy-D-Glucose in the Presence of Ofloxacin A GABAA Receptor Antagonist
The involvement of the γ-aminobutyric acid (GABA) receptors in the mediation of inhibitory activity in the central nervous system has been well documented (Nistri and Constanti, 1979; Tallman and Gallager, 198...
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Article
Improved positron emission tomography quantification by Fourier-based restoration filtering
Positron emission tomography (PET) images are characterized by both poor spatial resolution and high statistical noise. Conventional methods to reduce noise, such as local weighted averaging, produce further d...
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Article
Factor analysis of regional cerebral glucose metabolic rates in healthy men
Cerebral glucose utilization measured with fluorine-18-fluoro-2-deoxy-D-glucose is characterized by considerable variability both among different persons and for the same person examined on different occasions...
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Rest thallium-201 myocardial perfusion imaging in a patient with leukaemic infiltration of the heart
Despite the high incidence of leukaemic infiltration of the heart, only 8 cases of atrioventricular block due to leukaemia have been reported in the literature. Improvement in the heart block associated with d...
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Chapter
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Peripheral nerves serve as communication links between the central nervous system and the rest of the body. Once a nerve is severed, the functions innervated by it are lost. From the severed ends nearest the s...
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Article
Effects of atropine treatment on in vitro and in vivo binding of 4-[125I]-dexetimide to central and myocardial muscarinic receptors
Upregulation of muscarinic cholinergic receptors (mAChR) after chronic atropine treatment has been described previously. The present study was designed to evaluate 4-iodine-125 dexetimide as an agent to determ...
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Article
Indium-111 myosin-specific antibodies and technetium-99m pyrophosphate in the detection of acute cardiac rejection of transplanted hearts: studies in a heterotopic rat heart model
111In-labelled myosin-specific antibodies were evaluated as an indicator of early changes in acute rejection in a rat heart heterotopic transplant model. Uptake of antibodies was measured in allograft and isogra...
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Chapter
Special Problems Associated with the Synthesis of High Specific Activity Carbon-11 Labeled Radiotracers
Short-lived positron-emitting radiotracers allow researchers and clinicians access to previously unavailable information regarding problems in physiology, biochemistry, and pharmacology in the living human bod...
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Chapter
A Theoretically-Correct Algorithm to Compensate for a Three-Dimensional Spatially-Variant Point Spread Function in Spect Imaging
Three factors which degrade positional information and the quantitative potential of single photon emission computed tomography (SPECT) are finite detector size, Compton scatter, and the detector point spread ...
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Article
Monitoring effects of α-human atrial natriuretic polypeptide (α-hANP) on left ventricular function in patients with essential hypertension with a cardiac probe
The effects of α-hANP on left ventricular function were studied with a cardiac probe in ten patients with essential hypertension. Our data showed that intravenous administration of α-hANP significantly elevate...
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Article
Analysis of three- and four-compartment models forin vivo radioligand-neuroreceptor interaction
Currently applied three-copartment models for analyzing kinetic data derived fromin vivo positron emission tomographic (PET) studies of radioligand-neuroreceptor interactions require assumptions which may not be ...
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Article
Comparison of transaxial resolution in 180° and 360° SPECT with a rotating scintillation camera
Using circular 180° and 360° SPECT acquisition modes the transaxial resolution of line sources in air and water were measured at different positions in the field of view. With the 180° acquisition mode, all li...
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Article
On estimating the loss of quantification in PET due to finite detector resolution
In positron emission computed tomography, images and reconstructed from projection data of the slice. Such projection data are inherently subject to bias owing to the detection of coincident annihilation photo...
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Article
Linear discriminant analysis of regional ejection fractions in the diagnosis of coronary artery disease
We studied the application of linear discriminant analysis to the computer assisted interpretation of rest and exercise gated blood pool studies. Data were obtained in 45 patients in whom the presence or absen...
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Article
Absorbed fractions for dose calculations of neuroreceptor PET studies
A simple Monte Carlo program was constructed for the purpose of calculating absorbed fractions of relevance to neurologic positron-emission-tomography studies. The caudate, putamen, and cerebellum regions of t...
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Chapter
Regional Phagocytosis in Man
The phagocytic function of the reticuloendothelial cells in the liver, spleen, bone marrow, and lymph nodes can be examined by nuclear imaging. Since approximately 85–95% of the body’s phagocytic cells are loc...
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Article
Measurement of effects of the Chinese herbal medicine higenamine on left ventricular function using a cardiac probe
The effects of the Chinese herbal medicine higenamine on left ventricular function were studied by means of an external radiation detector in 15 patients with heart disease. Higenamine, administered intravenou...
