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Article
Open AccessGemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients
Fanconi anemia (FA) is a rare hereditary disease resulting from an inactivating mutation in the FA/BRCA pathway, critical for the effective repair of DNA interstrand crosslinks (ICLs). The disease is character...
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Article
Open AccessCD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors
CD4+ T cells can "help” or "license” conventional type 1 dendritic cells (cDC1s) to induce CD8+ cytotoxic T lymphocyte (CTL) anticancer responses, as proven in mouse models. We recently identified cDC1s with a tr...
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Article
Open AccessDRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age
Ageing is associated with changes in the cellular composition of the immune system. During ageing, hematopoietic stem and progenitor cells (HSPCs) that produce immune cells are thought to decline in their rege...
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Article
Open AccessSignals for antigen-independent differentiation of memory CD8+ T cells
Conventional CD8+ memory T cells develop upon stimulation with foreign antigen and provide increased protection upon re-challenge. Over the past two decades, new subsets of CD8+ T cells have been identified that ...
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Article
Open AccessAKT inhibition impairs PCNA ubiquitylation and triggers synthetic lethality in homologous recombination-deficient cells submitted to replication stress
Translesion DNA synthesis (TLS) and homologous recombination (HR) cooperate during S-phase to safeguard replication forks integrity. Thus, the inhibition of TLS becomes a promising point of therapeutic interve...
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Article
Open AccessElevated APOBEC3B Correlates with Poor Outcomes for Estrogen-Receptor-Positive Breast Cancers
Recent observations connected DNA cytosine deaminase APOBEC3B to the genetic evolution of breast cancer. We addressed whether APOBEC3B is associated with breast cancer clinical outcomes. APOBEC3B messenger RNA (m...
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Article
Reassessing genomic targeting of AID
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Article
Perturbation of B and T cell development and predisposition to lymphomagenesis in EμBmi1 transgenic mice require the Bmi1 RING finger
Proviral activation of the Bmi1 gene has implicated Bmi1 as a collaborator of c-Myc in lymphomagenesis. To determine the effect of Bmi1 overexpression on hema- topoiesis and lymphomagenesis transgenic mice were g...
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Article
Bcl-2 reduces lymphomagenesis in ΔV-TCRβ transgenic mice
Overexpression of the bcl-2 oncogene in the lymphoid compartment of transgenic mice prolongs the lifespan of lymphocytes and leads to a low incidence of lymphomas at later age. Transgenic mice carrying a mutated ...
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Article
Overexpression of the FosB2 gene in thymocytes causes aberrant development of T cells and thymic epithelial cells
We have examined the role of the AP-1 transcription factor on thymocyte maturation and thymus architecture by overexpressing FosB2 in transgenic mice. FosB2 is a naturally occurring splice variant of the FosB2...
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Article
The primary structure of a feline class I gene: Striking similarity toHLA-A
The sequence of a feline class I pseudogene and its comparison with class I genes from other species is presented. The gene isolated is a pseudogene because of the presence of four stop codons and two frame sh...
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Chapter
Results on the Performance of the Sulzer Cavity Receiver and the Franco-Tosi External Receiver
This paper presents some of the results of evaluation performed on the cavity receiver (Sulzer) and the external receiver (ASR) installed at the IEA/SSPS project. These two different receiver concepts were tes...
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Chapter
CRS Power Conversion System Losses
This paper presents a short discussion of the performance and results of evaluation performed on the power conversion system (PCS) of the IEA/SSPS central receiver system (CRS).
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Chapter
Thermal Losses of the Collector Fields
To improve the operational efficiency of the DCS plant, it is necessary to determine the sources of the thermal energy losses. The study described in this paper is directed at the energy loss that occurs when ...
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Chapter
Losses and Performance of the Power Conversion System
This paper presents results of evaluation performed on the power conversion system (PCS) of the IEA/SSPS distributed collector system (DCS). The steam generator of the PCS is fed by thermal oil coming from the...
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Chapter
Receiver Losses: Results of Tests
The objective is to evaluate the thermal losses from the receiver over the temperature range at which the receiver may operate. To achieve this, tests have been carried out with no concentrated power reaching ...
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Chapter
Pi** and Tank Losses
In this paper, the thermal losses for the main pi** and tanks in the CRS-system are presented. The main objective is to provide the necessary data for calculating the overall losses in the system at normal o...
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Chapter
Thermal Losses/Thermal Inertia
Quantifying the loss stair-step has been one of the important goals of the evaluation team at the SSPS project. This evaluation area addresses each of the loss elements as they were evaluated, and also discuss...
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Chapter
Receiver Behavior Comparison
Sodium has very attractive heat transfer characteristics, thus it is an obvious candidate cooling fluid for a high temperature, high performance, central receiver system. The SSPS project has operated with two...
