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    Article

    LMDS-1, a potential TrkB receptor agonist provides a safe and neurotrophic effect for early-phase Alzheimer’s disease

    The signaling pathways of tropomyosin-related kinase B (TrkB) receptor play a pivotal role in axonal sprouting, proliferation of dendritic arbor, synaptic plasticity, and neuronal differentiation. The levels o...

    Chia-Hao Fan, Chia-Wei Lin, Hei-Jen Huang, Guey-Jen Lee-Chen… in Psychopharmacology (2020)

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    Article

    Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases

    Many protein aggregation diseases (PAD) affect the nervous system. Deposits of aggregated disease-specific proteins are found within or around the neuronal cells of neurodegenerative diseases. Although the mai...

    Yu-Han Chung, Chia-Wei Lin, Hsin-Yu Huang… in Journal of Molecular Neuroscience (2020)

  3. Article

    Open Access

    Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice

    Hyperglycemia accelerates the progression of Alzheimer’s disease (AD), and GSK3β plays a potential link between AD and hyperglycemia. Therefore, a direct or indirect GSK3β inhibition may have potential to dela...

    Hei-Jen Huang, Shu-Ling Chen, Hsin-Yu Huang, Ying-Chieh Sun… in Psychopharmacology (2019)

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    Article

    Trehalose Attenuates the Gait Ataxia and Gliosis of Spinocerebellar Ataxia Type 17 Mice

    Spinocerebellar ataxia type 17 (SCA17) is caused by CAG/CAA repeat expansion on the gene encoding a general transcription factor, TATA-box-binding protein (TBP). The CAG repeat expansion leads to the reduced s...

    Zhi-Zhong Chen, Chien-Ming Wang, Guan-Chiun Lee, Ho-Chiang Hsu… in Neurochemical Research (2015)