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  1. No Access

    Protocol

    Drug Affinity Responsive Target Stability (DARTS) for Small-Molecule Target Identification

    Drug affinity responsive target stability (DARTS) is a relatively quick and straightforward approach to identify potential protein targets for small molecules. It relies on the protection against proteolysis c...

    Melody Y. Pai, Brett Lomenick, Heejun Hwang, Robert Schiestl… in Chemical Biology (2015)

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    Article

    The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

    Ageing in the worm Caenorhabditis elegans is shown to be delayed by supplementation with α-ketoglutarate, an effect that is probably mediated by ATP synthase—which is identified as a direct target of α-ketoglutar...

    Randall M. Chin, Xudong Fu, Melody Y. Pai, Laurent Vergnes, Heejun Hwang… in Nature (2014)