15 Result(s)
within
Hee Sup Shin
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessAuthor Correction: The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons
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Open AccessNon-invasive optical control of endogenous Ca2+ channels in awake mice
Optogenetic approaches for controlling Ca2+ channels provide powerful means for modulating diverse Ca2+-specific biological events in space and time. However, blue light-responsive photoreceptors are, in principl...
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Open AccessThe rostroventral part of the thalamic reticular nucleus modulates fear extinction
The thalamus has been implicated in fear extinction, yet the role of the thalamic reticular nucleus (TRN) in this process remains unclear. Here, in mice, we show that the rostroventral part of the TRN (TRNrv) ...
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Neural circuits underlying a psychotherapeutic regimen for fear disorders
A psychotherapeutic regimen that uses alternating bilateral sensory stimulation (ABS) has been used to treat post-traumatic stress disorder. However, the neural basis that underlies the long-lasting effect of ...
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Open AccessNoninvasive optical activation of Flp recombinase for genetic manipulation in deep mouse brain regions
Spatiotemporal control of gene expression or labeling is a valuable strategy for identifying functions of genes within complex neural circuits. Here, we develop a highly light-sensitive and efficient photoacti...
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Open AccessStress-induced changes in social dominance are scaled by AMPA-type glutamate receptor phosphorylation in the medial prefrontal cortex
The establishment and maintenance of social dominance are critical for social stability and the survival and health of individual animals. Stress lead to depression and a decrease in the social status of depre...
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Open AccessThe Possible Role of Neurobeachin in Extinction of Contextual Fear Memory
Established fear memory becomes vulnerable to disruption after memory retrieval and extinction; this labile state is critical for inhibiting the return of fear memory. However, the labile state has a very narr...
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Open AccessDeficiency of a brain-specific chemokine-like molecule, SAM3, induces cardinal phenotypes of autism spectrum disorders in mice
Chemokines are small secreted signaling proteins produced by a broad range of cells, including immune cells. Several studies have recently suggested potential roles of chemokines and their receptors in the pat...
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Open AccessMice in social conflict show rule-observance behavior enhancing long-term benefit
Disorderly resolution of conflict is costly, whereas orderly resolution by consent rules enables quick settlement. However, it is unclear whether non-human animals can make and observe rules to resolve conflic...
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Open AccessThe Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons
Neuronal firing patterns, which are crucial for determining the nature of encoded information, have been widely studied; however, the molecular identity and cellular mechanisms of spike-frequency adaptation ar...
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Open AccessLFP-guided targeting of a cortical barrel column for in vivo two-photon calcium imaging
Two-photon microscopy of bulk-loaded functional dyes is an outstanding physiological technique that enables simultaneous functional map** of hundreds of brain cells in vivo at single-cell resolution. However, p...
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Open AccessAutomated identification of multiple seizure-related and interictal epileptiform event types in the EEG of mice
Visual scoring of murine EEG signals is time-consuming and subject to low inter-observer reproducibility. The Racine scale for behavioral seizure severity does not provide information about interictal or sub-c...
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Phospholipase C isozymes selectively couple to specific neurotransmitter receptors
A variety of extracellular signals are transduced across the cell membrane by the enzyme phosphoinositide-specific phospholipase C-β (PLC-β) coupled with guanine-nucleotide-binding G proteins1. There are four iso...
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An unusual coding sequence from a Drosophila clock gene is conserved in vertebrates
The per locus has a fundamental involvement in the expression of biological rhythms in Drosophila. Mutations at this locus can shorten, lengthen or eliminate a variety of rhythmic activities that range from circa...
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Inversion in the H–2 complex of t-haplotypes in mice
Mouse t-haplotypes demonstrate strong linkage disequilibrium between t-lethal genes and specific H–2 types, presumably a result of recombination suppression between t and normal chromosomes1. The observation of f...
