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Article
Open AccessThe USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6
The control of Wnt receptor abundance is critical for animal development and to prevent tumorigenesis, but the mechanisms that mediate receptor stabilization remain uncertain. We demonstrate that stabilization...
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Article
Open AccessThe USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling
The relative abundance of Wnt receptors plays a crucial role in controlling Wnt signaling in tissue homeostasis and human disease. While the ubiquitin ligases that ubiquitylate Wnt receptors are well-character...
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Article
Open AccessThe E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling
Immunomodulatory drugs (IMiDs) are important for the treatment of multiple myeloma and myelodysplastic syndrome. Binding of IMiDs to Cereblon (CRBN), the substrate receptor of the CRL4CRBN E3 ubiquitin ligase, in...
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Article
Open AccessWnt pathway activation by ADP-ribosylation
Wnt/β-catenin signalling directs fundamental processes during metazoan development and can be aberrantly activated in cancer. Wnt stimulation induces the recruitment of the scaffold protein Axin from an inhibi...
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The Adenomatous Polyposis Coli Tumor Suppressor and Wnt Signaling in the Regulation of Apoptosis
The adenomatous polyposis coli (APC) tumor suppressor is an essential negative regulator in the evolutionarily conserved Wnt/Wingless (Wg) signal transduction pathway. During normal development, Wnt signaling ...
