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  1. Article

    Open Access

    Cooperative effects of oocytes and estrogen on the forkhead box L2 expression in mural granulosa cells in mice

    Forkhead box L2 (FOXL2) plays a critical role in the development and function of mammalian ovaries. In fact, the causative effects of FOXL2 misregulations have been identified in many ovarian diseases, such as...

    Haruka Ito, Chihiro Emori, Mei Kobayashi, Natsumi Maruyama in Scientific Reports (2022)

  2. Article

    Open Access

    Generation of genetically modified mice using SpCas9-NG engineered nuclease

    Although genetically modified mice can be generated with high efficiency by using CRISPR/Cas9-mediated genome editing in mouse zygotes, only the loci with a protospacer-adjacent motif (PAM) sequence are target...

    Wataru Fujii, Haruka Ito, Takuya Kanke, Arisa Ikeda, Koji Sugiura in Scientific Reports (2019)

  3. Article

    Open Access

    Derivation of induced pluripotent stem cells in Japanese macaque (Macaca fuscata)

    Non-human primates are our closest relatives and are of special interest for ecological, evolutionary and biomedical research. The Japanese macaque (Macaca fuscata) has contributed to the progress of primatology ...

    Risako Nakai, Mari Ohnuki, Kota Kuroki, Haruka Ito, Hirohisa Hirai in Scientific Reports (2018)