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Open AccessThe Diaphragmatic Initiated Ventilatory Assist (DIVA) trial: study protocol for a randomized controlled trial comparing rates of extubation failure in extremely premature infants undergoing extubation to non-invasive neurally adjusted ventilatory assist versus non-synchronized nasal intermittent positive pressure ventilation
Invasive mechanical ventilation contributes to bronchopulmonary dysplasia (BPD), the most common complication of prematurity and the leading respiratory cause of childhood morbidity. Non-invasive ventilation (...
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Article
Early brain and abdominal oxygenation in extremely low birth weight infants
Extremely low birth weight (ELBW) infants are at risk for end-organ hypoxia and ischemia. Regional tissue oxygenation of the brain and gut as monitored with near-infrared spectroscopy (NIRS) may change with po...
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Chapter
Noninvasive Ventilation: An Overview
This chapter covers methods of assisted ventilation without an endotracheal tube in the trachea and using interfaces either just at the nares or sealing the entire nose with a mask. These methods can deliver p...
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Chapter
Continuous Distending Pressure
Continuous distending pressure (CDP) is a pressure applied to the airways throughout the respiratory cycle. This chapter focuses on the non-invasive use of CDP using continuous positive airway pressure (CPAP)....
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Article
How to introduce MSC-based therapy for the develo** lung safely into clinical care?
Extreme prematurity is associated with an increased risk to develop bronchopulmonary dysplasia (BPD). Severe BPD is associated with a significant long-term burden for the affected infant, families and society....
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Article
The promise and pitfalls of precision medicine to resolve black–white racial disparities in preterm birth
Differences in preterm birth rates between black and white women are the largest contributor to racial disparities in infant mortality. In today’s age of precision medicine, analysis of the genome, epigenome, ...
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Article
Medication use in infants with severe bronchopulmonary dysplasia admitted to United States children’s hospitals
To identify the number of cumulative medication exposures and most frequently used medications in infants with severe BPD.
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Article
Factors influencing decision making in neonatology: inhaled nitric oxide in preterm infants
We studied decision making regarding inhaled nitric oxide (iNO) in preterm infants with Pulmonary Hypertension (PH).
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Article
Constructing a Culturally Informed Spanish Decision-Aid to Counsel Latino Parents Facing Imminent Extreme Premature Delivery
Objective How Latino parents perceive and understand antenatal counseling for extreme prematurity, < 26 weeks of gestational age (GA), is not clear. We aim to characterize Latino parental perceptions of antenatal...
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Article
Open AccessMilrinone in congenital diaphragmatic hernia – a randomized pilot trial: study protocol, review of literature and survey of current practices
Congenital diaphragmatic hernia (CDH) is commonly associated with pulmonary hypoplasia and pulmonary hypertension (PH). PH associated with CDH (CDH-PH) is frequently resistant to conventional pulmonary vasodil...
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Article
Open AccessSustained Aeration of Infant Lungs (SAIL) trial: study protocol for a randomized controlled trial
Extremely preterm infants require assistance recruiting the lung to establish a functional residual capacity after birth. Sustained inflation (SI) combined with positive end expiratory pressure (PEEP) may be a...
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Article
Sonographic and radiographic imaging features of the neonate with necrotizing enterocolitis: correlating findings with outcomes
Abdominal radiography is the reference standard in imaging neonates with necrotizing enterocolitis (NEC); however, ultrasound of the abdomen including bowel may be of value in this setting.
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Article
Open AccessStop** randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2)
Randomized clinical trials (RCTs) stopped early for benefit often receive great attention and affect clinical practice, but pose interpretational challenges for clinicians, researchers, and policy makers. Beca...
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Article
A Failure to Communicate? Characterizing the Parental Decision Making Process for Impending Extremely Preterm, Delivery
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A Directed Donation (DD) Program Reduces Allogeneic Blood Exposure In Neonatal Intensive Care † 1398
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Pulmonary Deposition of Salbutamol Aerosol Delivered by Metered Dose Inhaler, Jet Nebulizer, and Ultrasonic Nebulizer in Mechanically Ventilated Rabbits
The deposition efficiency of three methods of aerosol delivery of salbutamol into lungs of ventilated rabbits was compared: 1) metered dose inhaler (MDI) with holding chamber (HC), 2) jet nebulizer (JN), and 3) u...
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Article
[18F]Fluorodeoxyglucose Uptake in Neonatal Acute Lung Injury Measured by Positron Emission Tomography
The objective of this study was to evaluate positron emission tomography(PET) of [18F]fluorodexoyglucose (18FDG) uptake as a measure of neonatal acute lung injury. Inasmuch as intrapulmonary sequestration of neut...
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Article
COMPUTER AIDED MEASUREMENT OF LUNG VOLUMES FROM CHEST X-RAY 1530
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A META-ANALYSIS OF THERAPIES FOR PREVENTION AND TREATMENT OF THE ADULT RESPIRATORY DISTRESS SYNDROME 170
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RESCUE THERAPY WITH THE SERVO VENTILATOR 300 IN NEWBORN INFANTS WITH RESPIRATORY FAILURE: A RETROSPECTIVE REVIEW † 1036
