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Article

Diphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects

Diphthamide is a modified histidine residue unique for eukaryotic translation elongation factor 2 (eEF2), a key ribosomal protein. Loss of this evolutionarily conserved modification causes developmental defect...

Yu Shi, Daochao Huang, Cui Song, Ruixue Cao, Zhao Wang, Dan Wang… in Nature Communications (2024)