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Integration of Transformative Platforms for the Discovery of Causative Genes in Cardiovascular Diseases

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  1. Article

    Open Access

    Laminar Flow Attenuates Macrophage Migration Inhibitory Factor Expression in Endothelial Cells

    Macrophage migration inhibitory factor (MIF) is a non-canonical cytokine that is involved in multiple inflammatory diseases, including atherosclerosis. High MIF expression found in leukocytes which facilitates...

    Congzhen Qiao, Shengdi Li, Haocheng Lu, Fan Meng, Yanbo Fan… in Scientific Reports (2018)

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  2. Article

    Open Access

    MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk

    A major challenge in genetic association studies is that most associated variants fall in the non-coding part of the human genome. We searched for variants associated with bone mineral density (BMD) after enri...

    Ida Surakka, Lars G. Fritsche, Wei Zhou, Joshua Backman… in Nature Communications (2020)

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