16 Result(s)
within
Hao Guo
Neurosciences
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Article
Correction to: Recombinant Adiponectin Peptide Ameliorates Brain Injury Following Intracerebral Hemorrhage by Suppressing Astrocyte-Derived Inflammation via the Inhibition of Drp1-Mediated Mitochondrial Fission
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Article
Open AccessPaternal methamphetamine exposure induces higher sensitivity to methamphetamine in male offspring through driving ADRB1 on CaMKII-positive neurons in mPFC
Paternal abuse of drugs, such as methamphetamine (METH), elevates the risk of develo** addiction in subsequent generations, however, its underlying molecular mechanism remains poorly understood. Male adult m...
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Article
Open AccessComparison of Long-Term Outcomes of Endoscopic and Minimally Invasive Catheter Evacuation for the Treatment of Spontaneous Cerebellar Hemorrhage
Recently, minimally invasive techniques, including endoscopic evacuation and minimally invasive catheter (MIC) evacuation, have been used for the treatment of patients with spontaneous cerebellar hemorrhage (S...
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Article
Antagonism of Protease-Activated Receptor 4 Protects Against Traumatic Brain Injury by Suppressing Neuroinflammation via Inhibition of Tab2/NF-κB Signaling
Traumatic brain injury (TBI) triggers the activation of the endogenous coagulation mechanism, and a large amount of thrombin is released to curb uncontrollable bleeding through thrombin receptors, also known a...
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Article
Recombinant Adiponectin Peptide Ameliorates Brain Injury Following Intracerebral Hemorrhage by Suppressing Astrocyte-Derived Inflammation via the Inhibition of Drp1-Mediated Mitochondrial Fission
Intracerebral hemorrhage (ICH) is a life-threatening subtype of cerebral stroke with high morbidity and mortality; however, effective treatment for ICH is still lacking. Adiponectin (APN) is a a kind of fat-de...
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Article
Open AccessAcrolein Aggravates Secondary Brain Injury After Intracerebral Hemorrhage Through Drp1-Mediated Mitochondrial Oxidative Damage in Mice
Clinical advances in the treatment of intracranial hemorrhage (ICH) are restricted by the incomplete understanding of the molecular mechanisms contributing to secondary brain injury. Acrolein is a highly activ...
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Article
Graph-based network analysis of resting-state fMRI: test-retest reliability of binarized and weighted networks
In the past decade, resting-state functional magnetic resonance imaging (rs-fMRI) and graph-based measures have been widely used to quantitatively characterize the architectures of brain functional networks in...
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Article
The basolateral amygdala regulation of complex cognitive behaviours in the five-choice serial reaction time task
The basolateral amygdala (BLA) plays important roles in the cognitive control in human and non-human animals. However, inconsistent findings between species have been observed and there have been relatively fe...
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Chapter
Role of Cerebral Venous System in Hemorrhagic Stroke
Currently, neuroprotective strategies mainly aim to decrease bleeding from cerebral arteries and protect the insulted neurons in the hemorrhagic stroke. However, the role of cerebral venous system in the patho...
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Chapter
Role of Cerebral Venous System in Traumatic Brain Injury
Traumatic brain injury (TBI) is one of the most prevalent causes of neurological dysfunction, leading to substantial economic and social burdens worldwide. The brain edema, including cytotoxic and vascular bra...
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Chapter
Role of Cerebral Venous System in Neurodegenerative Disorders
The role of cerebral venous system in the pathogenesis of neurodegenerative diseases remains largely unknown and underinvestigated. Recent studies have suggested that several neurodegenerative disorders, such ...
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Article
Opiate-associated contextual memory formation and retrieval are differentially modulated by dopamine D1 and D2 signaling in hippocampal–prefrontal connectivity
Contextual memory driven by abused drugs such as opiates has a central role in maintenance and relapse of drug-taking behaviors. Although dopamine (DA) signaling favors memory storage and retrieval via regulat...
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Article
Pterostilbene Attenuates Early Brain Injury Following Subarachnoid Hemorrhage via Inhibition of the NLRP3 Inflammasome and Nox2-Related Oxidative Stress
Pterostilbene (PTE), one of the polyphenols present in plants such as blueberries and grapes, has been suggested to have various effects, such as anti-oxidation, anti-apoptosis, and anti-cancer effects. Subara...
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Article
Mitochondrial DNA Haplogroup A Decreases the Risk of Drug Addiction but Conversely Increases the Risk of HIV-1 Infection in Chinese Addicts
Drug addiction is one of the most serious social problems in the world today and addicts are always at a high risk of acquiring HIV infection. Mitochondrial impairment has been reported in both drug addicts an...
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Article
Open AccessA mouse line for inducible and reversible silencing of specific neurons
Genetic methods for inducibly and reversibly inhibiting neuronal activity of specific neurons are critical for exploring the functions of neuronal circuits. The engineered human glycine receptor, called iverme...
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Article
Open AccessCommon promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese
The NADH-ubiquinone oxidoreductase flavoprotein gene (NDUFV2), which encodes a 24 kD mitochondrial complex I subunit, has been reported to be positively associated with schizophrenia and bipolar disorder in diffe...
