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    Synthesis and antitumor activity of pyrano[3,2-i]-fused camptothecin derivatives

    A novel series of A-ring modified hexacyclic camptothecin derivatives containing a pyranone ring fused at the 9-positions and 10-positions were designed and synthesized. These new derivatives were screened aga...

    Bihong Hong, Guangrong Meng, Hanyi Tan, Jiajun Li… in Medicinal Chemistry Research (2019)