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Article
Open AccessImpact of glucose metabolism on PD-L1 expression in sorafenib-resistant hepatocellular carcinoma cells
Hepatocellular carcinoma (HCC) is the fifth leading cause of cancer-related mortality worldwide. Programmed cell death ligand-1 (PD-L1) is an immune checkpoint protein that binds to programmed cell death-1 (PD...
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Article
Open AccessAstrocytic scar restricting glioblastoma via glutamate–MAO-B activity in glioblastoma-microglia assembloid
Glial scar formation is a reactive glial response confining injured regions in a central nervous system. However, it remains challenging to identify key factors formulating glial scar in response to glioblasto...
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Article
Open AccessModified parylene-N films as chemical microenvironments for differentiation and spheroid formation of osteoblast cells
In this work, the influence of parylene N film on the spheroid formation of osteoblast-like cells (MG-63) was determined and compared with that of high-hydrophilicity microenvironments, such as hydrophilic cul...
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Article
Open AccessModulation of SIRT3 expression through CDK4/6 enhances the anti-cancer effect of sorafenib in hepatocellular carcinoma cells
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide. The only drug currently approved for clinical use in the treatment of advanced HCC is sorafenib. However, many patients w...
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Article
Open AccessThe critical role of glucose deprivation in epithelial-mesenchymal transition in hepatocellular carcinoma under hypoxia
Imaging with 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is used to determine sites of abnormal glucose metabolism to predict high tumor grade, metastasis, and poor p...
