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    Article

    PACAP/PAC1-R activation contributes to hyperalgesia in 6-OHDA-induced Parkinson’s disease model rats via promoting excitatory synaptic transmission of spinal dorsal horn neurons

    Pain is a common annoying non-motor symptom in Parkinson’s disease (PD) that causes distress to patients. Treatment for PD pain remains a big challenge, as its underlying mechanisms are elusive. Pituitary aden...

    Li-guo Dong, Meng-qi An, Han-ying Gu, Li-ge Zhang… in Acta Pharmacologica Sinica (2023)

  2. No Access

    Article

    Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson’s Disease

    Pain in Parkinson’s disease (PD) is increasingly recognized as a major factor associated with poor life quality of PD patients. However, classic therapeutic drugs supplying dopamine have limited therapeutic ef...

    Cheng-Jie Li, Li-Ge Zhang, Lu-Bing Liu, Meng-Qi An, Li-guo Dong… in Molecular Neurobiology (2022)