-
Article
Open AccessProteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ
The progression of urothelial bladder cancer (UC) is a complicated multi-step process. We perform a comprehensive multi-omics analysis of 448 samples from 190 UC patients, covering the whole spectrum of diseas...
-
Article
Open AccessStaged pain or systemic crisis? Research on the employment effect of enterprise green transformation
The green transformation is a necessary path for industrialization to reach the advanced stage. Currently, achieving a win-win situation between green transformation and stable employment for residents has bec...
-
Article
Open AccessComprehensive proteogenomic characterization of early duodenal cancer reveals the carcinogenesis tracks of different subtypes
The subtypes of duodenal cancer (DC) are complicated and the carcinogenesis process is not well characterized. We present comprehensive characterization of 438 samples from 156 DC patients, covering 2 major an...
-
Article
Open AccessIntegrative proteogenomic characterization of early esophageal cancer
Esophageal squamous cell carcinoma (ESCC) is malignant while the carcinogenesis is still unclear. Here, we perform a comprehensive multi-omics analysis of 786 trace-tumor-samples from 154 ESCC patients, coveri...
-
Article
Sirt3 mediates the benefits of exercise on bone in aged mice
Exercise in later life is important for bone health and delays the progression of osteoporotic bone loss. Osteocytes are the major bone cells responsible for transforming mechanical stimuli into cellular signa...
-
Article
Open AccessProteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues
Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are two main histological subtypes of solid cancer; however, SCCs are derived from different organs with similar morphologies, and it is challenging to dis...
-
Article
Open AccessIntegrated proteogenomic characterization of urothelial carcinoma of the bladder
Urothelial carcinoma (UC) is the most common pathological type of bladder cancer, a malignant tumor. However, an integrated multi-omics analysis of the Chinese UC patient cohort is lacking.
-
Article
Open AccessAn individual nomogram can reliably predict tumor spread through air spaces in non-small-cell lung cancer
Tumor spread through air spaces (STAS) has been shown to adversely affect the prognosis of lung cancer. The correlation between clinicopathological and genetic features and STAS remains unclear.
-
Article
Prognostic value and characterization of NTRK1 variation by fluorescence in situ hybridization in esophageal squamous cell carcinoma
Rearrangement of the neurotrophic tyrosine kinase receptor (NTRK) 1 gene is a target of tropomyosin receptor kinase A (TRKA) inhibitors, and its targeted drug (larotrectinib) has been approved by the US Food and ...
-
Article
Open AccessPrognostic value of visual residual tumour cells (VRTC) for patients with esophageal squamous cell carcinomas after neoadjuvant therapy followed by surgery
We assessed visual residual tumour cells (VRTC) with both Becker’s tumour regression grading (TRG) system and Japanese TRG system in esophageal squamous cell carcinoma (ESCC) patients treated with neoadjuvant ...
-
Article
Open AccessConditioned media from endothelial progenitor cells cultured in simulated microgravity promote angiogenesis and bone fracture healing
Paracrine signaling from endothelial progenitor cells (EPCs) is beneficial for angiogenesis and thus promotes tissue regeneration. Microgravity (MG) environment is found to facilitate the functional potentials...
-
Article
Triazole Hydrophilic Interaction Chromatography Mass Spectrometry–Based Method for Studying the Lipidomic Composition of Largemouth Bass (Micropterus salmoides) with Different Feeds
A triazole hydrophilic interaction chromatography mass spectrometry (HILIC-MS) method was developed for lipidomics studying the largemouth bass (Micropterus salmoides). The effect of feeds, especially the frozen ...
-
Article
Open AccessAdministration of allogeneic mesenchymal stem cells in lengthening phase accelerates early bone consolidation in rat distraction osteogenesis model
Distraction osteogenesis (DO) is a surgical technique to promote bone regeneration which may require long duration for bone consolidation. Bone marrow-derived mesenchymal stem cells (MSCs) have been applied to...
-
Article
In situ rapid evaporative ionization mass spectrometry method for real-time discrimination of Pelodiscus sinensis in different culturing modes without sample preparation
Rapid evaporative ionization mass spectrometry (REIMS) is a recently developed technology for real-time lipidomics profiling of biological tissues without time-consuming sample preparation. In this study, a RE...
-
Article
Asiatic Acid Attenuates Bone Loss by Regulating Osteoclastic Differentiation
Anti-resorptive agents like bisphosphonates have been widely used for the treatment of postmenopausal osteoporosis. However, their long-term safety and efficacy are still controversial. This study is to examin...
-
Article
SPHK-2 Promotes the Particle-Induced Inflammation of RAW264.7 by Maintaining Consistent Expression of TNF-α and IL-6
Aseptic implant loosening is a devastating long-term complication of total joint arthroplasty. It is mainly initiated by the interaction of wear debris and macrophages. However, how does the chronic inflammati...
-
Article
Protein Disulfide Isomerase Silence Inhibits Inflammatory Functions of Macrophages by Suppressing Reactive Oxygen Species and NF-κB Pathway
Macrophages play an essential role in inflammation. Protein disulfide isomerase (PDI) is central to the redox system, which is closely linked with the inflammatory function of macrophages. However, the relatio...
-
Article
A retrospective study of endoscopic resection for 368 patients with early esophageal squamous cell carcinoma or precancerous lesions
To retrospectively investigate the clinicopathological features and prognosis of early esophageal squamous cell neoplasm (ESCN) treated with endoscopic resection (ER), especially, to compare the prognosis in p...
-
Article
Open AccessTumour infiltrating lymphocytes correlate with improved survival in patients with esophageal squamous cell carcinoma
We undertook a study of tumour infiltrating lymphocytes (TILs) in a large and relatively homogeneous group of patients with completely resected esophageal squamous cell carcinoma (ESCC). Hematoxylin and eosin–...
-
Chapter and Conference Paper
Integrated Algorithms for Network Optimization of Dangerous Goods Transportation
Network Optimization of Dangerous Goods Transportation (NODGT) belongs to a class of problems referred to as NP-Hard, and strict constraint of it and then make it harder to solve. Considering the capacity of t...
