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Article
Open AccessYAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis
The senescence of alveolar type II (AT2) cells impedes self-repair of the lung epithelium and contributes to lung injury in the setting of idiopathic pulmonary fibrosis (IPF). Yes-associated protein 1 (YAP1) i...
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Article
lncRNA Gm20257 alleviates pathological cardiac hypertrophy by modulating the PGC-1α–mitochondrial complex IV axis
Pathological cardiac hypertrophy, a major contributor to heart failure, is closely linked to mitochondrial function. The roles of long noncoding RNAs (lncRNAs), which regulate mitochondrial function, remain la...
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Article
Preventive effects of Ramelteon on bleomycin-induced pulmonary fibrosis in mice
Pulmonary fibrosis (PF) is a devastating lung disease that leads to impaired lung function and ultimately death. Several studies have suggested that melatonin, a hormone involved in regulating sleep–wake cycle...
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Article
Open AccessLong non-coding RNA KCND1 protects hearts from hypertrophy by targeting YBX1
Cardiac hypertrophy is a common structural remodeling in many cardiovascular diseases. Recently, long non-coding RNAs (LncRNAs) were found to be involved in the physiological and pathological processes of card...
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Article
Open AccessRetraction Note: Systematic analyses reveal long non-coding RNA (PTAF)-mediated promotion of EMT and invasion-metastasis in serous ovarian cancer
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-018-0844-7.
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Article
Upregulation of CXCL1 and LY9 contributes to BRCAness in ovarian cancer and mediates response to PARPi and immune checkpoint blockade
Mutations in BRCA1 or BRCA2 (BRCA1/2) cause homologous recombination deficiency (HRD). Ovarian cancer (OvCa) patients harbouring HRD beyond BRCA1/2 mutation result in a state referred to as “BRCAness”. OvCa with ...
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Article
Open AccessGankyrin modulated non-small cell lung cancer progression via glycolysis metabolism in a YAP1-dependent manner
Non-small cell lung cancer (NSCLC) is highly malignant and heterogeneous form of lung cancer and involves various oncogene alterations. Glycolysis, an important step in tumor metabolism, is closely related to ...
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Article
Open AccessSystematic analyses identify the anti-fibrotic role of lncRNA TP53TG1 in IPF
Long non-coding RNA (lncRNA) was reported to be a critical regulator of cellular homeostasis, but poorly understood in idiopathic pulmonary fibrosis (IPF). Here, we systematically identified a crucial lncRNA, ...
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Article
The long non-coding RNA PFI protects against pulmonary fibrosis by interacting with splicing regulator SRSF1
Pulmonary fibrosis (PF) is a type of interstitial pneumonia with complex etiology and high mortality, characterized by progressive scarring of the alveolar interstitium and myofibroblastic lesions. Recently, t...
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Article
Open AccessLncRNA CTD-2528L19.6 prevents the progression of IPF by alleviating fibroblast activation
Long non-coding RNAs (lncRNAs) have emerged as critical factors for regulating multiple biological processes during organ fibrosis. However, the mechanism of lncRNAs in idiopathic pulmonary fibrosis (IPF) rema...
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Article
Open AccessCorrection to: LncRNA PTAR promotes EMT and invasionmetastasis in serous ovarian cancer by competitively binding miR-101-3p to regulate ZEB1 expression
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open AccessCorrection to: Systematic analyses reveal long non-coding RNA (PTAF)-mediated promotion of EMT and invasion-metastasis in serous ovarian cancer
An amendment to this paper has been published and can be accessed via the original article.
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Article
YAP1/Twist promotes fibroblast activation and lung fibrosis that conferred by miR-15a loss in IPF
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic parenchymal lung disease of unknown etiology and lack effective interventions. Using a combination of in vitro and in vivo studies, we fo...
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Article
Open AccessMelatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction
Pulmonary fibrosis is a progressive disease characterized by epithelial cell damage, fibroblast proliferation, excessive extracellular matrix (ECM) deposition, and lung tissue scarring. Melatonin, a hormone pr...
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Article
Open AccessLncRNA PTAR promotes EMT and invasion-metastasis in serous ovarian cancer by competitively binding miR-101-3p to regulate ZEB1 expression
Ovarian cancer (OvCa) is one of the most common malignant diseases of the female reproductive system in the world. The majority of OvCa is diagnosed with metastasis in the abdominal cavity. Epithelial-to-mesen...
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Article
Open AccessRETRACTED ARTICLE: Systematic analyses reveal long non-coding RNA (PTAF)-mediated promotion of EMT and invasion-metastasis in serous ovarian cancer
A deeper mechanistic understanding of epithelial-to-mesenchymal transition (EMT) regulation is needed to improve current anti-metastasis strategies in ovarian cancer (OvCa). This study was designed to investig...
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Article
Open AccessYAP1 contributes to NSCLC invasion and migration by promoting Slug transcription via the transcription co-factor TEAD
Yes-associated protein 1 (YAP1) contributes to the development of multiple tumors, but the mechanism underlying YAP1 deregulation in non-small cell lung cancer (NSCLC) remains unclear. By performing immunohist...
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Article
Open AccessDifferential expression analysis at the individual level reveals a lncRNA prognostic signature for lung adenocarcinoma
Deregulations of long non-coding RNAs (lncRNAs) have been implicated in cancer initiation and progression. Current methods can only capture differential expression of lncRNAs at the population level and ignore...
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Article
Open AccessEMT-Regulome: a database for EMT-related regulatory interactions, motifs and network
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Open AccessOver-expression of microRNA-1 causes arrhythmia by disturbing intracellular trafficking system
Dysregulation of intracellular trafficking system plays a fundamental role in the progression of cardiovascular disease. Up-regulation of miR-1 contributes to arrhythmia, we sought to elucidate whether intrace...
