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Article
Open AccessSingle-cell transcriptomics reveal distinct immune-infiltrating phenotypes and macrophage–tumor interaction axes among different lineages of pituitary neuroendocrine tumors
Pituitary neuroendocrine tumors (PitNETs) are common gland neoplasms demonstrating distinctive transcription factors. Although the role of immune cells in PitNETs has been widely recognized, the precise immuno...
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Article
Global sensitivity analysis using polynomial chaos expansion enhanced Gaussian process regression method
Global sensitivity analysis (GSA) is a commonly used approach to explore the contribution of input variables to the model output and identify the most important variables. However, performing GSA typically req...
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Article
Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic response in acute promyelocytic leukemia
The treatment of PML/RARA+ acute promyelocytic leukemia (APL) with all-trans-retinoic acid and arsenic trioxide (ATRA/ATO) has been recognized as a model for translational medicine research. Though an altered ...
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Article
Open AccessSubsidized gestational diabetes mellitus screening and management program in rural China: a pragmatic multicenter, randomized controlled trial
The increasing prevalence of gestational diabetes mellitus (GDM) is a major challenge, particularly in rural areas of China where control rates are suboptimal. This study aimed to evaluate the effectiveness of...
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Article
Prospective observational study on biomarkers of response in pancreatic ductal adenocarcinoma
Adjuvant chemotherapy benefits patients with resected pancreatic ductal adenocarcinoma (PDAC), but the compromised physical state of post-operative patients can hinder compliance. Biomarkers that identify cand...
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Article
Open AccessPriority index for critical Covid-19 identifies clinically actionable targets and drugs
While genome-wide studies have identified genomic loci in hosts associated with life-threatening Covid-19 (critical Covid-19), the challenge of resolving these loci hinders further identification of clinically...
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Article
Open AccessCellular hierarchy insights reveal leukemic stem-like cells and early death risk in acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) represents a paradigm for targeted differentiation therapy, with a minority of patients experiencing treatment failure and even early death. We here report a comprehensive si...
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Article
Open AccessFeatures and development trends of primary care research conducted by practice-based research networks from 1991 to 2023: a sco** review protocol
Practice-based research networks (PBRNs) have been recognized as essential laboratories and mechanisms for develo** primary care research. This sco** review aims to examine and map the features and develop...
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Article
Open AccessFactors associated with recommendation behaviors of four non-National Immunization Program vaccines: a cross-sectional survey among public health workers in China
Immunization is a crucial preventive measure to safeguard children under five years old against a range of diseases. In China, the coverage rate of non-National Immunization Program (non-NIP) vaccines can be i...
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Article
Open AccessHuman endogenous retroviruses as epigenetic therapeutic targets in TP53-mutated diffuse large B-cell lymphoma
TP53 mutation (TP53mut) occurs in 10–20% of diffuse large B-cell lymphoma (DLBCL) cases and serves as an unfavorable biomarker of DLBCL progression. It confers resistance to immunochemotherapy, high-dose chemothe...
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Article
Open AccessAssessing the impact of the 2018 Changchun Changsheng vaccine incident on childhood vaccination in China
The 2018 Changchun Changsheng vaccine incident is an emergent public health event in China with reports of DTaP vaccines with compromised efficacy. This study aimed to estimate the impact of the vaccine incide...
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Article
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial
There is a paucity of high-quality evidence on the effectiveness and safety of salt reduction strategies, particularly for older people, who have the most to benefit but are at higher risk of adverse effects. ...
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Article
Open AccessHypothesis-free phenotype prediction within a genetics-first framework
Cohort-wide sequencing studies have revealed that the largest category of variants is those deemed ‘rare’, even for the subset located in coding regions (99% of known coding variants are seen in less than 1% o...
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Article
Open AccessAxial compressive behavior of GFRP-timber-reinforced concrete composite columns
This paper investigated the compressive behavior of a novel glass fiber reinforced polymer (GFRP)-timber-reinforced concrete composite column (GTRC column), which consisted of reinforced concrete with an outer...
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Chapter
Fibre Reinforced Polymer Wall Assemblies in Axial Compression
Web-flange sandwich structures were built up by two glass fibre reinforced polymer (GFRP) panels and square hollow sections (SHS) in between through adhesive bonding or mechanical bolting. Experiments in compr...
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Article
Open AccessIdentification of a novel GR-ARID1a-P53BP1 protein complex involved in DNA damage repair and cell cycle regulation
ARID1a (BAF250), a component of human SWI/SNF chromatin remodeling complexes, is frequently mutated across numerous cancers, and its loss of function has been putatively linked to glucocorticoid resistance. He...
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Article
Open AccessMaterial product life cycle analysis driven by industrial internet of things
With the fast expansion of the industrial Internet of Things (IIoT) in recent years, the requirement for high-speed, dependable, low-latency, and full-coverage IIoT has grown more pressing. Because of the comp...
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Article
Open AccessEpigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance
Chromatin states and enhancers associate gene expression, cell identity and disease. Here, we systematically delineate the acute innate immune response to endotoxin in terms of human macrophage enhancer activi...
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Article
Analytical Modeling of Fluid Sloshing in A 2D Rectangular Container with A Bottom-Mounted T-Shaped Baffle
An analytical procedure is presented to evaluate the fluid sloshing characteristics in a two-dimensional (2D) rectangular container with a bottom-mounted T-shaped baffle. The fluid region is divided into sever...
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Article
A cost-efficient scheduling algorithm for streaming processing applications on cloud
Stream processing is a new memory computing paradigm that deals with dynamic data streams efficiently. Storm is one of the stream processing frameworks, but the default stream processing scheduler of storm als...
