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Article
Correlation between microRNA-34a levels and lens opacity severity in age-related cataracts
MicroRNA 34a (miR-34a) is involved in regulating tissue senescence. However, the role of miR-34a in age-related cataracts is unclear. In this study, we evaluated the correlations among the severity of lens opa...
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Article
Open AccessAdjuvant chemotherapy for gastric cancer: a randomised phase 3 trial of mitomycin-C plus either short-term doxifluridine or long-term doxifluridine plus cisplatin after curative D2 gastrectomy (AMC0201)
This phase 3 study evaluated the efficacy of new adjuvant chemotherapy (MFP), which intensified the mitomycin-C (MMC) plus short-term doxifluridine (Mf) for gastric cancer.
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Article
Egr-1 mediates epidermal growth factor-induced downregulation of E-cadherin expression via Slug in human ovarian cancer cells
Loss of the cell adhesion protein E-cadherin increases the invasive capability of ovarian cancer cells. We have previously shown that epidermal growth factor (EGF) downregulates E-cadherin and induces ovarian ...
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Article
The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients
Large-artery stiffness is a risk factor for stroke, including cerebral small-vessel disease. Retinal microvascular changes are thought to mirror those in cerebral microvessels. We investigated the relationship...
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Article
Open AccessPhase II and UGT1A1 genotype study of irinotecan dose escalation as salvage therapy for advanced gastric cancer
To assess the efficacy and safety of individualised dose optimisation of irinotecan monotherapy as salvage treatment for advanced gastric cancer (AGC).
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Article
Open AccessPhase II study of everolimus with biomarker exploration in patients with advanced gastric cancer refractory to chemotherapy including fluoropyrimidine and platinum
To evaluate the activity and safety of everolimus and identify potential biomarkers for efficacy of everolimus in patients with advanced gastric cancer (AGC), who failed both fluoropyrimidine and platinum.
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Article
Open AccessPhase II study of S-1 combined with oxaliplatin as therapy for patients with metastatic biliary tract cancer: influence of the CYP2A6 polymorphism on pharmacokinetics and clinical activity
Advanced biliary cancer is often treated with fluoropyrimidine-based chemotherapy. In this study, we evaluated the efficacy and tolerability of a combination of S-1, an oral fluoropyrimidine prodrug, and oxali...
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Article
Open AccessA randomised multicentre phase II trial of capecitabine vs S-1 as first-line treatment in elderly patients with metastatic or recurrent unresectable gastric cancer
This randomised multicentre phase II study was conducted to investigate the activity and safety of two oral fluoropyrimidines, capecitabine or S-1, in elderly patients with advanced gastric cancer (AGC). Elder...
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Article
Open AccessA phase II study of paclitaxel and capecitabine as a first-line combination chemotherapy for advanced gastric cancer
Paclitaxel and capecitabine, which have distinct mechanisms of action and toxicity profiles, have each shown high activity as single agents in gastric cancer. Synergistic interaction between these two drugs wa...
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Article
Metastatic choroidal abscess and choroidal neovascularization in a patient with Staphylococcus aureus renal abscess
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Article
Open AccessPhase II study of capecitabine and cisplatin as first-line combination therapy in patients with gastric cancer recurrent after fluoropyrimidine-based adjuvant chemotherapy
To evaluate the efficacy and safety of capecitabine and cisplatin in patients with recurrent gastric cancer after fluoropyrimidine-based adjuvant therapy. Patients with histologically confirmed and measurable ...
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Chapter and Conference Paper
Two-Stage Refrigeration for Subcooling Liquid Hydrogen and Oxygen as Densified Propellants
The thermodynamic design on two-stage refrigeration cycles is performed as one of several feasibility studies for the densified propellant technologies funded by the NASA Glenn Research Center. The refrigerati...
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Chapter
Optimal Integration of Binary Current Lead and Cryocooler
An optimal integration of a binary current lead and a two-stage cryocooler has been analytically sought to minimize the required refrigerator power. The binary current lead is a series combination of a normal ...
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Chapter
Experimental Study of the Heat Transfer in Pulse Tubes
The present study has been conducted to observe the details of heat transfer under pulsating pressure and oscillating flow in a pulse tube. An experimental apparatus was fabricated to measure the gas temperatu...
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Chapter
Optimization of Two-Stage Conduction Cooling for HTS Current Leads
An optimal two-stage cooling method for HTS current leads is developed to minimize the required refrigerator power input. The lead is a series combination of a normal metal conductor at the warmer part and an ...
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Chapter
Optimal Design of Sizes in Binary Current Leads Cooled by Cryogenic Refrigerator
Analysis is performed to determine the optimal lengths or cross-sectional areas of refrigerator-cooled current leads that can be applied to the conduction-cooled superconducting systems. The binary current lea...
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Chapter
Conceptual Design Analysis of 4K Irradiation Facility in Korean Hanaro Research Reactor
A conceptual design of a 4 K irradiation test facility has been conducted in support of the International Thermonuclear Experimental Reactor (ITER) magnet development program. A new research reactor designated...
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Chapter
A Stirling Cycle Analysis with Gas-Wall Heat Transfer in Compressor and Expander
A cycle analysis that includes the gas-wall heat transfer in compressors and expanders of Stirling cryocoolers is presented. The gas-wall heat transfer in the working spaces is quite different from the convent...
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Chapter
An Exact Expression for Shuttle Heat Transfer
A new and general analytical expression is obtained for the shuttle heat transfer rate in displacer-cylinder systems. The shuttle heat transfer occurs when the displacer has a reciprocating motion over the cyl...
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Article
Lipid-ion channel interactions: Increasing phospholipid headgroup size but not ordering acyl chains alters reconstituted channel behavior
We have recently shown (Chang et al., 1995) that lipid-channel interactions, exemplified by the effects of cholesterol on the calcium-activated potassium (BK) channel, profoundly affect channel properties. The...
