18 Result(s)

Article

Diabetic retinopathy in type 1 diabetes—a contemporary analysis of 8,784 patients

The aim of this study was to analyse the risk profile for diabetic retinopathy under real-life conditions in a large cohort of patients with type 1 diabetes.

H. P. Hammes, W. Kerner, S. Hofer, O. Kordonouri, K. Raile, R. W. Holl in Diabetologia (2011)

Article

Low-dose erythropoietin inhibits oxidative stress and early vascular changes in the experimental diabetic retina

Diabetic retinopathy is the result of increased oxidative and nitrosative stress induced by chronic hyperglycaemia, and affects the vasculature and the neuroglia. Erythropoietin is a neuroprotective and an end...

Q. Wang, F. Pfister, A. Dorn-Beineke, F. vom Hagen, J. Lin, Y. Feng… in Diabetologia (2010)

Article

Effect of R-(+)-α-lipoic acid on experimental diabetic retinopathy

Hyperglycaemia-induced mitochondrial overproduction of reactive oxygen species (ROS) is central to the pathogenesis of endothelial damage in diabetes. R-(+)-α-lipoic acid has advantages over classic antioxidan...

J. Lin, A. Bierhaus, P. Bugert, N. Dietrich, Y. Feng, F. vom Hagen… in Diabetologia (2006)

Article

Kinetics of integrin expression in the mouse model of proliferative retinopathy and success of secondary intervention with cyclic RGD peptides

Vitronectin-receptor-type integrins (α_v β ₃ and α_v β ₅) are thought to be involved in the selective ablation of tumorigenic and other pathol...

E. Chavakis, B. Riecke, J. Lin, T. Linn, R. G. Bretzel, K. T. Preissner… in Diabetologia (2002)

Article

Release of the angiogenesis inhibitor angiostatin in patients with proliferative diabetic retinopathy: association with retinal photocoagulation

Aims/hypothesis. Proliferative diabetic retinopathy is a major debilitating disease causing most cases of blindness in humans in the Western world. Photocoagulation is the established therapy of ...

J. Spranger, H.-P. Hammes, K. T. Preissner, H. Schatz, A. F. H. Pfeiffer in Diabetologia (2000)

Article

35th Annual Meeting of the European Association for the Study of Diabetes

A. Melander, J. Olsson, G. Lindberg, A. Salzman, T. Howard, P. Stang… in Diabetologia (1999)

Article

Differential accumulation of advanced glycation end products in the course of diabetic retinopathy

Aims/hypothesis. Glycated proteins, formed by reaction of glucose and protein, react further yielding numerous, mostly undefined advanced glycation end products (AGE). The recently characterized ...

H.-P. Hammes, A. Alt, T. Niwa, J. T. Clausen, R. G. Bretzel, M. Brownlee… in Diabetologia (1999)

Article

Diabetic retinopathy risk correlates with intracellular concentrations of the glycoxidation product Ne-(carboxymethyl) lysine independently of glycohaemoglobin concentrations

Aims/hypothesis. We investigated whether either the amount of diabetes-induced intracellular oxidative stress or the concentration of hyperglycaemia-induced advanced glycation endproducts is asso...

H.-P. Hammes, M. Brownlee, J. Lin, E. Schleicher, R. G. Bretzel in Diabetologia (1999)

Article

The relationship of glycaemic level to advanced glycation end-product (AGE) accumulation and retinal pathology in the spontaneous diabetic hamster

To assess the relationship between glucose and advanced glycation end products (AGE) and the relationship between AGE and retinal changes in vivo, we studied the time course of retinopathy over 12 months in t...

H.-P. Hammes, B. Wellensiek, I. Klöting, E. Sickel, R. G. Bretzel… in Diabetologia (1998)

Article

Antioxidant treatment of experimental diabetic retinopathy in rats with nicanartine

In order to study the contribution of oxidant stress to the pathogenesis of experimental diabetic retinopathy, male streptozotocin diabetic Lewis rats were treated with the antioxidant and lipid-lowering comp...

H. P. Hammes, A. Bartmann, L. Engel, P. Wülfroth in Diabetologia (1997)