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  1. No Access

    Article

    Effect of tyrosine kinase inhibitors on stemness in normal and chronic myeloid leukemia cells

    Although tyrosine kinase inhibitors (TKIs) efficiently cure chronic myeloid leukemia (CML), they can fail to eradicate CML stem cells (CML-SCs). The mechanisms responsible for CML-SC survival need to be unders...

    L Charaf, F-X Mahon, I Lamrissi-Garcia, I Moranvillier, F Beliveau, B Cardinaud… in Leukemia (2017)

  2. No Access

    Article

    Catalase overexpression reduces UVB-induced apoptosis in a human xeroderma pigmentosum reconstructed epidermis

    Xeroderma pigmentosum type C (XPC) is a rare autosomal recessive disorder that occurs due to inactivation of the XPC protein, an important DNA damage recognition protein involved in DNA nucleotide excision rep...

    H R Rezvani, C Ged, B Bouadjar, H de Verneuil, A Taïeb in Cancer Gene Therapy (2008)

  3. No Access

    Article

    Hematopoietic stem cell gene therapy of murine protoporphyria by methylguanine-DNA-methyltransferase-mediated in vivo drug selection

    Erythropoietic protoporphyria (EPP) is an inherited defect of the ferrochelatase (FECH) gene characterized by the accumulation of toxic protoporphyrin in the liver and bone marrow resulting in severe skin phot...

    E Richard, E Robert, M Cario-André, C Ged, F Géronimi, S L Gerson… in Gene Therapy (2004)

  4. No Access

    Article

    Lentivirus-mediated gene transfer of uroporphyrinogen III synthase fully corrects the porphyric phenotype in human cells

    Congenital erythropoietic porphyria (CEP) is an inherited disease due to a deficiency in the uroporphyrinogen III synthase, the fourth enzyme of the heme biosynthesis pathway. It is characterized by accumulati...

    F. Géronimi, E. Richard, I. Lamrissi-Garcia, M. Lalanne… in Journal of Molecular Medicine (2003)

  5. No Access

    Article

    Successful therapeutic effect in a mouse model of erythropoietic protoporphyria by partial genetic correction and fluorescence-based selection of hematopoietic cells

    Erythropoietic protoporphyria is characterized clinically by skin photosensitivity and biochemically by a ferrochelatase deficiency resulting in an excessive accumulation of photoreactive protoporphyrin in ery...

    A Fontanellas, M Mendez, F Mazurier, M Cario-André, S Navarro, C Ged… in Gene Therapy (2001)

  6. No Access

    Article

    Rapid analysis and efficient selection of human transduced primitive hematopoietic cells using the humanized S65T green fluorescent protein

    We have developed an efficient and rapid method to analyze transduction in human hematopoietic cells and to select them. We constructed two retroviral vectors using the recombinant humanized S65T green fluores...

    F Mazurier, F Moreau-Gaudry, V Maguer-Satta, S Salesse… in Gene Therapy (1998)

  7. No Access

    Article

    Gene transfer of the uroporphyrinogen III synthase cDNA into haematopoietic progenitor cells in view of a future gene therapy in congenital erythropoietic porphyria

    Congenital erythropoietic porphyria (CEP) is an inherited metabolic disorder characterized by an overproduction and accumulation of porphyrins in bone marrow. This autosomal recessive disease results from a de...

    F. Mazurier, F. Moreau-Gaudry, S. Salesse… in Journal of Inherited Metabolic Disease (1997)

  8. No Access

    Article

    Correction of the enzyme deficit of bone marrow cells in congenital erythropoietic porphyria by retroviral gene transfer

    F. Moreau-Gaudry, C. Barbot, F. Mazurier, F. X. Mahon… in Hematology and Cell Therapy (1996)

  9. No Access

    Article

    Is genoty** useful for the screening of medium-chain acyl-CoA dehydrogenase deficiency in France?

    C. Ged, H. El Sebai, H. de Verneuil… in Journal of Inherited Metabolic Disease (1995)

  10. No Access

    Article

    The cDNA sequence of mouse uroporphyrinogen III synthase and assignment to mouse Chromosome 7

    M. Bensidhoum, C. M. Ged, C. Poirier, J. -L. Guénet, H. de Verneuil in Mammalian Genome (1994)

  11. No Access

    Article

    Assignment of the gene for uroporphyrinogen decarboxylase to human chromosome 1 by somatic cell hybridization and specific enzyme immunoassay

    A specific enzyme immunoassay of uroporphyrinogen decarboxylase was developed and applied to the detection of the human enzyme in man-rodent somatic cell hybrids. This method allowed to assign the gene for uro...

    H. de Verneuil, B. Grandchamp, Chantal Foubert, Dominique Weil… in Human Genetics (1984)

  12. No Access

    Article

    Assignment of the human coproporphyrinogen oxidase to chromosome 9

    By using somatic cell hybrids between human fibroblasts and hamster or mouse cells, we have assigned the gene for human coproporphyrinogen oxidase to chromosome 9.

    B. Grandchamp, Dominique Weil, Y. Nordmann, N. Van Cong, H. de Verneuil… in Human Genetics (1983)

  13. No Access

    Article

    Assignment of human uroporphyrinogen I synthase locus to region 11qter by gene dosage effect

    Recently Meisler et al. (1980) reported the results of mouse/human somatic cell hybrid studies which indicated that the locus for human uroporphyrinogen I synthase (UPS) (EC 4.3.1.8) maps to chromosome 11. To ...

    H. de Verneuil, N. Phung, Y. Nordmann, D. Allard, F. Leprince, H. Jérome… in Human Genetics (1982)

  14. No Access

    Article

    The inherited enzymatic defect in porphyria variegata

    Protoporphyrinogen oxidase activity and ferrochelatase activity have been measured in blood lymphocytes from patients with porphyria variegata, and from some members of the family of one patient; the mean acti...

    J. Ch. Deybach, H. de Verneuil, Y. Nordmann in Human Genetics (1981)

  15. No Access

    Article

    Familial and sporadic porphyria cutanea

    Uroporphyrinogen (URO) decarboxylase was measured in hemoglobin-free erythrocytes from subjects with familial porphyria cutanea: the mean activity was about 50% of that found in erythrocytes from normal subjec...

    H. de Verneuil, G. Aitken, Y. Nordmann in Human Genetics (1978)