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Article
Application of boronated anti-CEA immunoliposome to tumour cell growth inhibition in in vitro boron neutron capture therapy model
An immunoliposome containing a 10B-compound has been examined as a selective drug delivery system in boron neutron-capture therapy. Liposomes, conjugated with monoclonal antibodies specific for carcinoembryoni...
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Targeting of Boronated Anti-Afp MoAB to Hepatoma Cells: Applications of Boronated MoAB for BNCT
The cytotoxic effects of boron neutron capture on cancer cells were first reported by Locher 1 and Kruger 2. Cell destruction in boron neutron capture therapy (BNCT) is due to the nuclear reaction between 10B and...
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Article
A targeting model of boron neutron-capture therapy to hepatoma cellsin vivo with a boronated anti-(α-fetoprotein) monoclonal antibody
We described previously that10B atoms delivered by monoclonal antibody (mAb) exerted a cytotoxic effect on AH66 cells in a dose-dependent manner upon thermal neutron irradiationin vitro. In the present study, the...
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Article
Inhibition of human pancreatic cancer growth in nude mice by boron neutron capture therapy
Immunoliposomes were prepared by conjugating anti-carcinoembryonic antigen (CEA) monoclonal antibody with liposomes containing [10B]compound. These immunoliposomes were shown to bind selectively to human pancr...
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Article
Regulation of mouse immuno-responses by a natural suppressor cell clone from bone marrow
Natural suppressor (NS) activity is mediated by several kinds of cell lineages in bone marrow. We demonstrated that a NS cell, clone 7–31, was obtained after limiting dilution with bone marrow culture suppleme...